GNH USA

Europe — EMA

Melkart Duo

GNH USA supplies Melkart Duo (Metformin Hydrochloride/Vildagliptin), a biguanide/DPP‑4 inhibitor for type 2 diabetes mellitus.

Metformin Hydrochloride, Vildagliptin

Request sourcing

1
Pack/s

What is Metformin Hydrochloride, Vildagliptin?

Metformin Hydrochloride and Vildagliptin, the active ingredients in Melkart Duo, are a biguanide and a DPP‑4 inhibitor presented as an oral tablet for oral use. They treat type 2 diabetes mellitus in adult patients by improving blood glucose control when combined with diet and exercise. It is indicated for patients whose glycemic levels are not adequately controlled by monotherapy.

GNH USA supplies Melkart Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets.

What is Metformin Hydrochloride, Vildagliptin used for?

Melkart Duo is used in the management of type 2 diabetes mellitus, a chronic metabolic disorder requiring glycemic control.

- Type 2 diabetes mellitus: improves overall glycemic control when added to diet and exercise. - Inadequate response to metformin alone: provides additional glucose lowering through DPP‑4 inhibition. - Combination therapy with other antidiabetics: helps achieve target HbA1c levels when used alongside insulin or sulfonylureas.

What are the side effects of Metformin Hydrochloride, Vildagliptin?

The most frequently reported adverse reactions with Melkart Duo involve the gastrointestinal system and mild systemic symptoms.

Common Side Effects: - Nausea - Diarrhea - Abdominal discomfort - Headache

Serious or Rare Side Effects: - Lactic acidosis - Severe hypoglycemia - Acute pancreatitis

What precautions apply to Metformin Hydrochloride, Vildagliptin?

When prescribing Melkart Duo, several safety considerations should be observed.

- Renal function: assess baseline creatinine clearance and monitor regularly. - Hepatic impairment: use with caution and monitor liver enzymes. - Hypoglycemia risk: observe closely when combined with insulin or sulfonylureas. - Lactic acidosis: discontinue immediately if symptoms such as malaise, myalgia, or rapid breathing appear. - Pregnancy and lactation: evaluate risk–benefit before prescribing. - Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

What does Metformin Hydrochloride, Vildagliptin interact with?

Melkart Duo may interact with several medicines; awareness of these interactions helps optimize therapy.

Major Interactions (Avoid): - Insulin or sulfonylureas: increased risk of severe hypoglycemia. - Iodinated contrast agents: may precipitate metformin‑associated renal dysfunction. - Cimetidine: can raise metformin plasma concentrations.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask hypoglycemia symptoms. - Diuretics: may affect renal clearance of metformin.

Frequently asked questions

What is Melkart Duo used for?+
Melkart Duo is an oral fixed‑dose combination of metformin hydrochloride and vildagliptin indicated for the treatment of type 2 diabetes mellitus in adult patients. It is prescribed when diet, exercise, and monotherapy with either component do not achieve adequate glycaemic control, helping to lower fasting and post‑prandial blood glucose levels.
How does Metformin Hydrochloride work?+
Metformin hydrochloride lowers blood glucose primarily by inhibiting hepatic gluconeogenesis, reducing the amount of glucose released by the liver. It also enhances peripheral insulin sensitivity, facilitating greater glucose uptake by muscle and adipose tissue, and modestly decreases intestinal absorption of glucose, contributing to overall glycaemic reduction.
How does Vildagliptin work?+
Vildagliptin is a selective dipeptidyl peptidase‑4 (DPP‑4) inhibitor. By blocking DPP‑4, it prevents the rapid degradation of endogenous incretin hormones (GLP‑1 and GIP), which in turn increases insulin secretion and suppresses glucagon release in a glucose‑dependent manner, improving post‑prandial glucose control.
What determines the usual dose of Melkart Duo?+
The specific dose of Melkart Duo is individualized by the prescribing clinician based on factors such as the patient’s current glycaemic status, renal function, concomitant medications, and response to therapy. The prescriber determines the appropriate tablet strength and dosing frequency, and adjustments are made during follow‑up visits.
Is Melkart Duo safe during pregnancy or breastfeeding?+
Safety of Melkart Duo in pregnancy and lactation has not been fully established. Clinicians should weigh potential benefits against possible risks, considering alternative treatments when possible. If therapy is deemed necessary, it should be used under close medical supervision, and breastfeeding mothers should be monitored for any adverse effects in the infant.
How do I order Melkart Duo from GNH USA?+
To order Melkart Duo, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required temperature control) and assistance with import documentation.
How does Melkart Duo compare with other antidiabetic options?+
Compared with sulfonylureas, Melkart Duo offers glucose‑dependent insulin secretion, reducing the risk of hypoglycaemia. Unlike metformin monotherapy, the addition of vildagliptin provides further post‑prandial glucose reduction. Relative to other DPP‑4 inhibitor combinations, the fixed‑dose format simplifies dosing and may improve adherence, though efficacy and safety profiles remain comparable across agents within the same class.
What are the recommended storage conditions for Melkart Duo?+
Melkart Duo tablets should be stored at ambient temperature, preferably below 25 °C, in their original blister or container to protect from moisture and light. Do not expose the product to excessive heat, humidity, or direct sunlight, and keep it out of reach of children. No refrigeration is required for this oral formulation.
How should Melkart Duo be administered?+
Melkart Duo is taken orally, usually with a meal to minimise gastrointestinal discomfort. The tablet should be swallowed whole with a full glass of water; it should not be crushed, chewed, or split unless specifically instructed by a healthcare professional. Adherence to the prescribed dosing schedule is important for optimal glycaemic control.
What are the most serious risks associated with Melkart Duo?+
The most serious risks associated with Melkart Duo include lactic acidosis, a rare but potentially fatal condition linked to metformin, and severe hypoglycaemia, especially when combined with insulin or sulfonylureas. Acute pancreatitis has also been reported with DPP‑4 inhibitors. Patients should be educated to recognize early symptoms and seek immediate medical attention if they occur.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Metformin Hydrochloride, Vildagliptin
Route
Oral Use
Manufacturer
G.L. Pharma Gmbh
Origin
EU

Related products

A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU
A

A

Liquid Extract From Viscum Album Subsp. Abietis Var Abies Alba (1:20), Extraction Solvents: Water Fo

Helixor Heilmittel Gmbh
EU