Melatonine

Melatonin, the active ingredient in Melatonine, is a melatonin receptor agonist presented as an oral formulation for oral use. It treats insomnia and related sleep‑wake rhythm disorders in adults.

GNH USA supplies Melatonine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Melatonin acts on the melatonin receptor pathway to regulate circadian rhythm and support normal sleep patterns. - Insomnia: helps initiate and maintain sleep in individuals with difficulty falling asleep. - Sleep‑wake rhythm disorders: assists in normalising disrupted sleep cycles such as delayed sleep phase. - Jet lag: reduces the time needed to adjust to new time zones after long‑distance travel.

Melatonin is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects: - Drowsiness during daytime - Headache - Dizziness - Nausea - Vivid dreams - Mild gastrointestinal discomfort

Serious or Rare Side Effects: - Allergic skin reactions (rash, itching) - Mood changes (depression, anxiety) - Hormonal disturbances (menstrual irregularities) - Severe hypersensitivity (anaphylaxis, though extremely rare).

Before using melatonin, consider the following safety points. - Pregnancy: consult a healthcare professional as safety data are limited. - Breastfeeding: discuss potential exposure with a physician. - Pediatric use: only under medical supervision. - Concomitant CNS depressants: monitor for enhanced sedation. - Underlying medical conditions: inform your doctor of any chronic illnesses. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Melatonin may interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may increase bleeding risk. - Immunosuppressants (e.g., cyclosporine): could reduce drug efficacy.

Moderate Interactions (Monitor Closely): - CNS depressants (e.g., benzodiazepines, alcohol): may enhance drowsiness. - Oral contraceptives: melatonin may affect hormone levels. - Antidiabetic agents: possible alteration of glucose control. - Antihypertensives: monitor blood pressure changes.