Europe — EMA
Melatonine
GNH USA supplies Melatonine (Melatonin), a melatonin receptor agonist for insomnia, sleep-wake rhythm disorders and jet lag.
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What is Melatonin?
Melatonin, the active ingredient in Melatonine, is a melatonin receptor agonist presented as an oral formulation for oral use. It treats insomnia and related sleep‑wake rhythm disorders in adults.
GNH USA supplies Melatonine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Melatonin used for?
Melatonin acts on the melatonin receptor pathway to regulate circadian rhythm and support normal sleep patterns. - Insomnia: helps initiate and maintain sleep in individuals with difficulty falling asleep. - Sleep‑wake rhythm disorders: assists in normalising disrupted sleep cycles such as delayed sleep phase. - Jet lag: reduces the time needed to adjust to new time zones after long‑distance travel.
What are the side effects of Melatonin?
Melatonin is generally well tolerated, but some users may experience adverse reactions.
Common Side Effects: - Drowsiness during daytime - Headache - Dizziness - Nausea - Vivid dreams - Mild gastrointestinal discomfort
Serious or Rare Side Effects: - Allergic skin reactions (rash, itching) - Mood changes (depression, anxiety) - Hormonal disturbances (menstrual irregularities) - Severe hypersensitivity (anaphylaxis, though extremely rare).
What precautions apply to Melatonin?
Before using melatonin, consider the following safety points. - Pregnancy: consult a healthcare professional as safety data are limited. - Breastfeeding: discuss potential exposure with a physician. - Pediatric use: only under medical supervision. - Concomitant CNS depressants: monitor for enhanced sedation. - Underlying medical conditions: inform your doctor of any chronic illnesses. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.
What does Melatonin interact with?
Melatonin may interact with other medicines; awareness of the interaction level helps manage risk.
Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may increase bleeding risk. - Immunosuppressants (e.g., cyclosporine): could reduce drug efficacy.
Moderate Interactions (Monitor Closely): - CNS depressants (e.g., benzodiazepines, alcohol): may enhance drowsiness. - Oral contraceptives: melatonin may affect hormone levels. - Antidiabetic agents: possible alteration of glucose control. - Antihypertensives: monitor blood pressure changes.
