Melatonin

Melatonin, the active ingredient in Melatonin, is a melatonin receptor agonist presented as a / for oral use. It treats sleep onset insomnia, jet lag, and circadian rhythm sleep‑wake disorders in adults and adolescents.

GNH USA supplies Melatonin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Melatonin acts on the melatonin receptor system to regulate sleep‑wake timing. - Sleep onset insomnia: helps initiate sleep and improve sleep latency. - Jet lag: reduces the time needed to adjust to new time zones. - Circadian rhythm sleep‑wake disorders: stabilises abnormal circadian patterns and promotes more regular sleep timing.

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Drowsiness or daytime sleepiness. - Headache. - Dizziness. - Nausea. - Vivid dreams or nightmares.

Serious or Rare Side Effects: - Allergic reactions such as rash, itching, or swelling. - Mood changes including depression or anxiety. - Hormonal effects like menstrual irregularities. - Severe dizziness leading to falls. - Unexplained chest discomfort.

Use melatonin with consideration of individual health status and potential interactions. - Pregnancy: consult a healthcare professional before use. - Breastfeeding: discuss risks and benefits with a clinician. - Pediatric use: only under medical supervision. - Elderly: start with the lowest effective dose. - Concomitant CNS depressants: monitor for enhanced sedation. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Melatonin may interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may increase bleeding risk. - Immunosuppressants (e.g., cyclosporine): potential reduction in efficacy. - Central nervous system depressants (e.g., benzodiazepines): risk of excessive sedation.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: possible alteration of blood glucose control. - Hormonal contraceptives: may affect hormone levels. - CYP1A2 inhibitors (e.g., fluvoxamine): can raise melatonin plasma concentrations.