Melatonin

Melatonin, the active ingredient in Melatonin, is a melatonin receptor agonist presented as a tablet for oral use. It helps regulate the circadian rhythm and is used to promote sleep onset in adults experiencing insomnia, jet lag, or other circadian‑related sleep disturbances.

GNH USA supplies Melatonin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing consistent quality and regulatory compliance for global distribution. The company adheres to EU GMP standards and offers batch‑specific certificates of analysis for each shipment.

Melatonin is a melatonin receptor agonist used to address sleep‑related disorders.

Insomnia: improves sleep onset and maintenance in adults with difficulty falling or staying asleep. Jet lag: assists in realigning the circadian rhythm after rapid east‑west travel. Circadian rhythm sleep disorder: supports sleep regulation in shift‑work or delayed sleep phase syndrome.

Melatonin is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Drowsiness or daytime sleepiness - Headache - Dizziness - Nausea or mild gastrointestinal discomfort - Vivid dreams or nightmares - Mild fatigue

Serious or Rare Side Effects: - Allergic reactions such as rash, itching, or swelling - Severe daytime somnolence affecting alertness - Mood changes including depression or anxiety - Hallucinations or confusion (rare) - Abnormal heart rhythm or palpitations (very rare)

When using melatonin, consider the following precautions.

Assess sleep disorder before initiating therapy: confirm diagnosis and suitability. Avoid operating machinery or driving if drowsy: monitor for impaired alertness. Use with caution in hepatic impairment: metabolism may be altered. Not recommended for children unless prescribed by a specialist. Avoid concurrent use with other sedatives without medical advice. Store at room temperature: keep in the original pack, protect from moisture.

Melatonin may interact with other medications; monitor accordingly.

Major Interactions (Avoid): - Concurrent use with benzodiazepines or other sedative hypnotics: risk of excessive sedation. - Co‑administration with anticoagulants (e.g., warfarin): possible increased bleeding risk.

Moderate Interactions (Monitor Closely): - Antidepressants (SSRIs, SNRIs): may alter melatonin metabolism. - Oral contraceptives: can increase melatonin plasma levels. - Anticonvulsants (e.g., carbamazepine): may reduce melatonin effectiveness. - Caffeine-containing products: may diminish sleep‑promoting effect. - NSAIDs: may increase risk of gastrointestinal upset.