Melatal

Melatonin, the active ingredient in Melatal, is a melatonin receptor agonist presented as an oral formulation for oral use. It helps regulate the sleep‑wake cycle and is used to treat sleep disorders such as insomnia in adults. By binding to MT1 and MT2 receptors in the suprachiasmatic nucleus, it supports the natural circadian rhythm, facilitating the onset and maintenance of sleep.

GNH USA supplies Melatal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is manufactured under EU regulations and meets the quality standards required for global distribution.

Melatal is indicated for several sleep‑related conditions that involve disruption of the circadian rhythm.

- Primary insomnia: assists adults in initiating and maintaining sleep, improving total sleep time. - Delayed sleep phase disorder: advances sleep onset timing, helping align the internal clock with desired bedtime. - Jet lag: reduces the time needed to adjust to new time zones, promoting quicker adaptation of the sleep‑wake cycle.

Melatonin may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Drowsiness: feeling unusually sleepy during daytime. - Headache: mild to moderate pain in the head region. - Dizziness: sensation of light‑headedness or imbalance. - Nausea: feeling of stomach upset or urge to vomit.

Serious or Rare Side Effects: - Allergic reactions: rash, itching, swelling, or difficulty breathing. - Mood changes: emergence of depression, agitation, or anxiety. - Hormonal effects: alterations in reproductive hormone levels, potentially affecting menstrual cycles.

When prescribing Melatal, clinicians should consider several safety aspects to minimize risk.

- Age limitation: use is generally recommended for adults; pediatric use should be evaluated by a physician. - Concomitant CNS depressants: monitor for enhanced sedation. - Anticoagulant therapy: assess bleeding risk when combined. - Pregnancy and lactation: avoid unless benefits outweigh potential risks. - Underlying medical conditions: evaluate hepatic or renal impairment before use. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and light.

Melatonin can interact with other medicines, altering their effects or increasing adverse reactions.

Major Interactions (Avoid): - Warfarin: may increase bleeding risk. - Immunosuppressants (e.g., cyclosporine): potential reduction in immunosuppressive efficacy. - Oral contraceptives: possible hormonal interaction affecting contraceptive reliability.

Moderate Interactions (Monitor Closely): - Sedative antihistamines: enhanced drowsiness. - Antidiabetic agents: risk of hypoglycemia, requiring glucose monitoring.