Meladura

Melatonin, the active ingredient in Meladura, is a melatonin receptor agonist presented as an oral dosage form for oral use. It is used to help regulate sleep‑wake cycles and is indicated for adults experiencing insomnia, jet lag, or other sleep disorders.

GNH USA supplies Meladura as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable sourcing for global healthcare providers. Our distribution network ensures timely delivery across multiple continents.

Melatonin acts on the melatonin receptor pathway to support normal sleep regulation.

- Insomnia: helps reduce sleep onset latency and improve sleep maintenance in adults. - Jet lag: assists in resetting the circadian rhythm after rapid east‑west travel, reducing daytime fatigue. - Sleep disorders: supports overall sleep quality in individuals with circadian rhythm sleep‑wake disorders.

Oral melatonin may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Drowsiness or daytime sleepiness - Headache - Dizziness - Nausea or stomach discomfort - Vivid dreams or nightmares

Serious or Rare Side Effects: - Allergic reactions such as rash, itching or swelling - Severe skin reactions (e.g., Stevens‑Johnson syndrome) - Mood changes including depression or suicidal thoughts - Hormonal disturbances affecting menstrual cycle

When using melatonin, certain precautions should be observed to ensure safe and effective use.

- Assess sleep patterns: evaluate the underlying cause of sleep difficulty before initiating therapy. - Avoid operating machinery: refrain from driving or using heavy equipment if residual drowsiness occurs. - Pregnancy and breastfeeding: consult a healthcare professional before use, as safety data are limited. - Concomitant CNS depressants: use with caution when combined with alcohol, benzodiazepines or antihistamines. - Medical conditions: discuss use with a physician if you have epilepsy, depression or autoimmune disorders. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Melatonin can interact with several medicines, altering its effectiveness or increasing adverse effects.

Major Interactions (Avoid): - Concurrent use with CNS depressants (e.g., benzodiazepines, barbiturates) may cause excessive sedation. - Combination with anticoagulants such as warfarin may increase bleeding risk.

Moderate Interactions (Monitor Closely): - Alcohol consumption can enhance melatonin‑induced drowsiness. - CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin) may raise melatonin plasma levels. - CYP1A2 inducers (e.g., rifampin, carbamazepine) may reduce melatonin efficacy.