Meladine Sr

Metformin Hydrochloride, the active ingredient in Meladine Sr, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adults. GNH USA supplies Meladine Sr as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Metformin is a biguanide antidiabetic that improves glycaemic control in type 2 diabetes and related metabolic conditions.

Type 2 diabetes mellitus: improves blood glucose control and reduces HbA1c. Prediabetes (impaired glucose tolerance): lowers the risk of progression to overt diabetes. Polycystic ovary syndrome: improves insulin resistance and may help regulate menstrual cycles.

Metformin is generally well tolerated, but a range of adverse reactions have been reported.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Diarrhea: frequent loose stools, especially at treatment initiation. - Abdominal discomfort: cramping or bloating. - Metallic taste: transient alteration of taste perception. - Weight loss: modest reduction in body weight. - Vitamin B12 deficiency: decreased absorption with long‑term use.

Serious or Rare Side Effects: - Lactic acidosis: rare but potentially fatal metabolic acidosis. - Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic failure: marked elevation of liver enzymes. - Hypoglycaemia: when combined with insulin or sulfonylureas. - Pancreatitis: inflammation of the pancreas. - Severe gastrointestinal bleeding: uncommon but reported.

Metformin should be used with caution and under medical supervision.

Renal function assessment: avoid or adjust dose in patients with impaired kidney function. Hepatic function monitoring: use cautiously in liver disease due to lactic acidosis risk. Lactic acidosis risk: discontinue if patient develops severe infection, hypoxia, or acute heart failure. Blood glucose monitoring: regular checks to assess therapeutic response. Alcohol consumption: limit intake as alcohol can increase lactic acidosis risk. Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Metformin may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Iodinated contrast agents: can precipitate acute renal failure and lactic acidosis. - Cimetidine: increases metformin plasma concentrations. - Alcohol: heightens risk of lactic acidosis. - Carbamazepine: may reduce metformin efficacy. - Rifampin: may decrease metformin plasma levels.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask hypoglycaemia symptoms. - Diuretics: can affect renal clearance of metformin. - ACE inhibitors: monitor renal function and electrolytes. - NSAIDs: may impair renal function, increasing metformin exposure. - Warfarin: occasional reports of altered INR, monitor coagulation status.