GNH USA

Europe — EMA

Megestil

GNH USA supplies Megestil (Megestrol Acetate), a progestin for cachexia, breast cancer and endometrial cancer. Request a quote for global supply today.

Megestrol Acetate

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What is Megestrol Acetate?

Megestrol acetate, the active ingredient in Megestil, is a progestin presented as an oral tablet for oral use. It is employed in hormone therapy to manage cachexia associated with AIDS or cancer, and as part of treatment regimens for certain breast and endometrial cancers in adult patients, and may improve quality of life.

GNH USA supplies Megestil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide with reliable logistics and regulatory support.

What is Megestrol Acetate used for?

Megestil (megestrol acetate) acts as a progestogenic hormone therapy used in specific oncologic and wasting conditions.

- Cachexia (AIDS or cancer): improves appetite, promotes weight gain, and helps stabilize nutritional status in patients experiencing severe wasting. - Breast cancer: provides antigonadotropic effects that can help control hormone‑responsive tumor growth and may be used in advanced disease settings. - Endometrial cancer: used as part of hormonal management to inhibit disease progression, particularly in patients unsuitable for surgery or radiation.

What are the side effects of Megestrol Acetate?

Megestil may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nausea - Edema - Weight gain - Fatigue

Serious or Rare Side Effects: - Thromboembolic events - Hyperglycemia - Severe allergic reactions (anaphylaxis)

What precautions apply to Megestrol Acetate?

When using Megestil, consider the following precautions: - Monitor weight and fluid status: assess for excessive weight gain or edema regularly. - Check blood glucose: screen for hyperglycemia, especially in diabetic patients. - Evaluate for thromboembolic risk: consider prophylaxis in high‑risk individuals. - Observe adrenal function: prolonged use may suppress cortisol production. - Review concomitant hormone therapies: avoid additive hormonal effects. - Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

What does Megestrol Acetate interact with?

Megestil can interact with other medicines; awareness of major and moderate interactions helps ensure safety.

Major Interactions (Avoid): - Anticoagulants (warfarin): may increase bleeding risk. - CYP3A4 inducers (rifampin, carbamazepine): can reduce drug exposure. - Strong glucocorticoids: additive immunosuppressive effects.

Moderate Interactions (Monitor Closely): - Antidiabetic agents: may exacerbate hyperglycemia. - Hormonal contraceptives: may decrease contraceptive efficacy. - Digoxin: potential alteration of serum levels.

Frequently asked questions

What is Megestil used for?+
Megestil contains megestrol acetate, a progestin indicated for the management of cachexia associated with AIDS or cancer, and as part of hormonal therapy for certain breast and endometrial cancers. It helps improve appetite, promote weight gain, and may slow the progression of hormone‑responsive tumors.
How does megestrol acetate work?+
Megestrol acetate binds to intracellular progesterone receptors, producing antigonadotropic effects that lower estrogen and androgen levels. It also has glucocorticoid‑like activity, which stimulates appetite and protein synthesis, thereby counteracting catabolic states and influencing hormone‑driven tumor growth.
What determines the dose of Megestil?+
The appropriate dose of Megestil is individualized by the prescribing clinician based on the specific indication, severity of the condition, patient weight, renal and hepatic function, and any concomitant therapies. Dosage regimens are not standardized and should follow the prescriber’s written order.
Is Megestil safe during pregnancy or breastfeeding?+
The safety of megestrol acetate in pregnancy and lactation has not been established. Because the drug can affect hormonal balance, it is generally avoided in pregnant or nursing women unless the potential benefit outweighs the potential risk, as determined by a qualified health professional.
How do I order Megestil from GNH USA?+
To order Megestil, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Megestil compare with other treatments for cachexia?+
Megestil (megestrol acetate) is a progestogenic appetite stimulant, whereas other cachexia therapies may include corticosteroids, ghrelin mimetics, or nutritional interventions. Compared with corticosteroids, megestrol often provides longer‑lasting appetite improvement with a different side‑effect profile, but individual response varies and treatment choice depends on patient factors.
How should Megestil be stored and handled?+
Megestil tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.
How is Megestil administered?+
Megestil is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.
What are the most serious risks to watch for while taking Megestil?+
Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, significant hyperglycemia that may require medical intervention, and severe allergic reactions including anaphylaxis. Patients should seek immediate medical attention if they experience sudden swelling, shortness of breath, high blood sugar symptoms, or signs of an allergic reaction.
Who should not use Megestil?+
Megestil is contraindicated in individuals with known hypersensitivity to megestrol acetate or any excipients, in patients with active thromboembolic disease, uncontrolled diabetes, or severe liver dysfunction. It should also be used with caution in patients receiving other hormonal agents or anticoagulants, and only under medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Megestrol Acetate
Route
Oral Use
Manufacturer
Teofarma S.R.L.
Origin
EU

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