Megace

Megestrol acetate, the active ingredient in Megace, is a progestin presented as an oral tablet for oral use. It treats cachexia and weight loss associated with cancer or AIDS and is employed in certain hormone‑responsive cancers such as advanced breast and endometrial cancer.

GNH USA supplies Megace as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Megace is a synthetic progestogen used in conditions where appetite stimulation or hormonal control of tumor growth is required.

- Cachexia/weight loss associated with cancer or AIDS: helps increase appetite and promote weight gain. - Advanced breast cancer: provides antineoplastic activity to slow disease progression. - Endometrial cancer: used as hormonal therapy to control tumor growth.

Megace may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Nausea - Fatigue - Peripheral edema - Increased blood glucose levels - Headache - Dyspepsia

Serious or Rare Side Effects: - Thromboembolic events (deep vein thrombosis, pulmonary embolism) - Adrenal insufficiency or cortisol suppression - Severe allergic reactions, including anaphylaxis

Before initiating therapy, clinicians should evaluate several safety aspects.

- Monitor blood glucose: patients with diabetes may require dose adjustments. - Assess thromboembolic risk: avoid in individuals with a history of clotting disorders. - Evaluate liver function: hepatic impairment can alter drug metabolism. - Use caution in pregnancy: potential fetal risk, prescribe only if benefits outweigh risks. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Megace can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): may increase clotting risk. - CYP3A4 inducers (e.g., rifampin, phenytoin): can reduce Megace effectiveness. - Antidiabetic agents (insulin, sulfonylureas): may exacerbate hyperglycemia.

Moderate Interactions (Monitor Closely): - Corticosteroids: additive glucocorticoid effects may increase adverse events. - Hormonal contraceptives: Megace may diminish contraceptive efficacy.