Mefoxin

Cefoxitin Sodium, the active ingredient in Mefoxin, is a second‑generation cephalosporin presented as an injectable formulation for intramuscular use. It treats a range of bacterial infections in adults and children as directed by a healthcare professional.

GNH USA supplies Mefoxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Cefoxitin Sodium is used to treat infections caused by susceptible bacteria in several organ systems.

- Respiratory tract infections: effective against community‑acquired pneumonia and bronchitis. - Urinary tract infections: clears uncomplicated UTIs caused by susceptible strains. - Skin and soft tissue infections: resolves cellulitis and wound infections. - Intra‑abdominal infections: manages peritonitis and postoperative intra‑abdominal infections. - Gynecologic infections: treats pelvic inflammatory disease and postoperative gynecologic infections.

Adverse reactions may occur with intramuscular cefoxitin administration.

Common Side Effects: - Injection site pain: localized discomfort at the injection site. - Diarrhea: mild to moderate loose stools. - Nausea: feeling of queasiness. - Rash: non‑specific skin eruption.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Clostridioides difficile‑associated diarrhea: severe colitis linked to antibiotic use. - Neutropenia: marked reduction in neutrophil count, increasing infection risk.

Cefoxitin Sodium should be used with caution in specific patient populations.

- Renal impairment: adjust dose or monitor renal function closely. - Hepatic dysfunction: use with caution in patients with liver disease. - Allergy history: avoid in patients with known cephalosporin or beta‑lactam allergy. - Pregnancy and lactation: safety not established; prescribe only if benefit outweighs risk. - Concomitant nephrotoxic drugs: monitor kidney function when used together. - Store at ambient temperature: keep in original container, protect from moisture and light.

Cefoxitin Sodium may interact with other medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid): - Carbapenems (e.g., imipenem): antagonistic antibacterial effect. - Aminoglycosides: increased risk of nephrotoxicity. - Warfarin: potential enhancement of anticoagulant effect.

Moderate Interactions (Monitor Closely): - Loop diuretics: may affect renal clearance of cefoxitin. - Oral contraceptives: possible reduction in contraceptive efficacy. - Probenecid: may increase cefoxitin plasma concentrations.