Meflam (Mefenamic Acid)

Mefenamic acid, the active ingredient in Meflam, is a non‑steroidal anti‑inflammatory drug presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain, menstrual discomfort and inflammation associated with conditions such as arthritis.

GNH USA supplies Meflam as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Meflam, an NSAID, acts on inflammatory pathways to provide analgesic and anti‑inflammatory effects. - Mild to moderate pain: provides relief in acute or chronic pain conditions. - Dysmenorrhea (menstrual pain): reduces uterine cramping and associated discomfort. - Arthritic inflammation: alleviates joint swelling and pain in inflammatory arthritis.

Adverse reactions may occur with any NSAID and vary in frequency and severity.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or mild pruritus.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Renal impairment or acute kidney injury. - Severe skin reactions such as Stevens‑Johnson syndrome. - Hepatic dysfunction or elevated liver enzymes. - Anaphylactic or severe allergic reactions. - Cardiovascular events such as hypertension or thrombotic episodes.

Before prescribing Meflam, clinicians should consider patient‑specific risk factors and monitor for potential complications. - Assess renal function: adjust use in patients with impaired kidney function. - Monitor gastrointestinal risk: avoid in patients with active ulcer disease or a history of GI bleeding. - Avoid concurrent anticoagulants: increased bleeding risk. - Use caution in elderly: higher susceptibility to adverse effects. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Meflam can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors: may reduce renal function when combined. - Diuretics: may impair renal clearance of mefenamic acid.