Mefac

Mefenamic Acid, the active ingredient in Mefac, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It is indicated for mild to moderate pain, dysmenorrhea and inflammatory musculoskeletal conditions in adult patients.

GNH USA supplies Mefac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mefac, an NSAID, is employed to manage pain and inflammation across several clinical settings.

- Dysmenorrhea: provides relief from menstrual cramps and associated pelvic pain. - Musculoskeletal pain: reduces discomfort from strains, sprains and overuse injuries. - Mild to moderate pain: alleviates headache, dental pain and postoperative discomfort. - Inflammatory conditions: helps control swelling and pain in arthritis and other inflammatory disorders.

Mefac may cause a range of adverse reactions, from mild to severe, depending on individual susceptibility.

Common Side Effects: - Gastrointestinal upset: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or pruritus. - Diarrhoea or constipation. - Elevated liver enzymes.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Acute renal impairment or failure. - Severe hepatic injury. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Anaphylactic or anaphylactoid reactions. - Blood dyscrasias such as agranulocytosis.

Before prescribing Mefac, clinicians should consider several safety measures.

- Renal function assessment: evaluate baseline kidney status, especially in elderly patients. - Gastrointestinal risk: avoid in individuals with a history of peptic ulcer disease or bleeding. - Hypersensitivity: discontinue if signs of allergic reaction appear. - Anticoagulant use: monitor closely when combined with warfarin or other blood thinners. - Elderly patients: use the lowest effective dose and limit treatment duration. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Mefac can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Lithium: elevated lithium serum concentrations. - Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - Diuretics: possible reduction in renal perfusion. - Corticosteroids: additive risk of ulceration. - SSRIs or SNRIs: enhanced bleeding tendency. - ACE inhibitors or ARBs: potential for reduced renal function. - Oral hypoglycemics: may affect blood glucose control.