Mefac

Mefenamic acid, the active ingredient in Mefac, is a nonsteroidal anti‑inflammatory drug presented as an oral tablet for systemic use. It is employed to relieve mild to moderate pain, including menstrual pain, and to reduce inflammation in various acute conditions.

GNH USA supplies Mefac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to European Union quality standards and provides regulatory‑approved batches for global distribution. This ensures consistent potency and safety across markets.

Mefac, a nonsteroidal anti‑inflammatory drug, is indicated for several pain‑related and inflammatory conditions.

- Mild to moderate pain: provides analgesic relief for acute musculoskeletal discomfort. - Dysmenorrhea (menstrual pain): reduces uterine cramping and associated pain. - Inflammatory conditions: alleviates swelling and pain in acute inflammatory states such as sprains.

Mefac may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or pruritus. - Elevated liver enzymes. - Diarrhoea: loose stools. - Peripheral oedema: mild swelling of lower limbs.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hypersensitivity reactions, including Stevens‑Johnson syndrome. - Renal impairment or acute kidney injury. - Hepatotoxicity with jaundice. - Anaphylaxis or life‑threatening allergic response.

Before prescribing Mefac, clinicians should consider several safety precautions to minimise risk.

- Assess gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding. - Monitor renal function: use cautiously in those with impaired kidney function. - Evaluate hepatic status: avoid in severe liver disease. - Caution in cardiovascular disease: NSAIDs may increase thrombotic risk. - Avoid concomitant use with other NSAIDs or anticoagulants unless medically justified. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Mefac can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): additive bleeding potential.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: may reduce renal perfusion. - Lithium: NSAIDs can raise lithium serum levels. - Methotrexate: reduced clearance leading to toxicity. - Corticosteroids: increased risk of ulceration.