Medulan

Diclofenac Sodium, the active ingredient in Medulan, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a topical formulation for skin application. It is used to relieve pain and reduce inflammation in musculoskeletal conditions and is applied directly to the affected area. GNH USA supplies Medulan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac Sodium is a topical NSAID that acts on inflammatory pathways in the musculoskeletal system. - Musculoskeletal pain: alleviates pain and improves function in muscles, tendons and joints. - Localized inflammation: reduces swelling and erythema in inflamed tissues. - Arthritis: provides symptomatic relief of joint pain and stiffness associated with osteoarthritis and rheumatoid arthritis.

Topical diclofenac can cause local and systemic adverse reactions.

Common Side Effects: - Skin irritation: redness, itching or mild burning at the application site. - Dryness or peeling of the skin. - Pruritus (itching). - Localized rash. - Sensation of warmth or tingling.

Serious or Rare Side Effects: - Allergic reactions: urticaria, angioedema, or anaphylaxis. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Systemic effects: gastrointestinal ulceration or bleeding, especially with extensive use. - Cardiovascular events: increased risk of thrombotic events in susceptible individuals. - Hepatic or renal impairment: abnormal liver enzymes or reduced kidney function.

When using Medulan, consider the following safety measures. - Assess skin integrity: avoid application on broken, infected or severely irritated skin. - Limit application area: do not exceed the recommended surface area to reduce systemic absorption. - Avoid concurrent oral NSAIDs: discuss with a healthcare professional before combining therapies. - Monitor patients with liver or kidney disease: use with caution and under medical supervision. - Pregnant or breastfeeding women: consult a physician before use. - Store at room temperature: keep in the original packaging, protect from moisture and direct heat.

Diclofenac Sodium may interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Oral anticoagulants (e.g., warfarin): increased risk of bleeding. - Systemic NSAIDs or aspirin: heightened gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): potential for enhanced bleeding risk.

Moderate Interactions (Monitor Closely): - Corticosteroids: may increase ulceration risk. - ACE inhibitors or diuretics: possible reduction in renal function. - Lithium: diclofenac may raise lithium serum levels.