Medovir

Aciclovir, the active ingredient in Medovir, is an antiviral presented as an injection solution for intravenous use. It treats herpes simplex virus infections, varicella‑zoster virus infections and related conditions in patients requiring systemic therapy.

GNH USA supplies Medovir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Aciclovir is indicated for viral infections caused by herpes viruses and is administered intravenously for systemic disease control.

- Herpes simplex virus infections: reduces lesion duration and viral shedding. - Varicella‑zoster virus infections (chickenpox): limits disease severity and accelerates recovery. - Herpes zoster: alleviates pain and speeds healing of skin lesions. - Herpes encephalitis: improves survival rates and neurological outcomes.

Common Side Effects: - Injection site pain: mild discomfort at the infusion site. - Fever: transient elevation of body temperature. - Headache: mild to moderate intensity. - Nausea: occasional upset stomach. - Vomiting: occasional episodes. - Rash: mild skin erythema.

Serious or Rare Side Effects: - Nephrotoxicity: impaired kidney function, especially with high doses. - Thrombocytopenia: reduced platelet count leading to bleeding risk. - Severe allergic reactions: anaphylaxis or angioedema. - Seizures: rare neurologic events. - Hepatic dysfunction: elevated liver enzymes or hepatitis.

Before initiating therapy, consider patient-specific factors and monitor for adverse events. - Renal function monitoring: assess creatinine clearance and adjust dose as needed. - Hydration status: ensure adequate fluid intake to reduce nephrotoxicity risk. - Dose adjustment in renal impairment: modify regimen based on renal function. - Hypersensitivity avoidance: discontinue if signs of allergic reaction appear. - Pregnancy considerations: safety unknown; use only if benefits outweigh potential risks. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Aciclovir may interact with other medicines that affect renal clearance or increase toxicity.

Major Interactions (Avoid): - Probenecid: reduces renal excretion, raising aciclovir plasma levels. - Cimetidine: may increase serum concentrations of aciclovir. - Concurrent nephrotoxic agents (e.g., aminoglycosides): heightened risk of kidney injury.

Moderate Interactions (Monitor Closely): - NSAIDs: can impair renal function, requiring closer monitoring. - Valproic acid: may increase risk of neurotoxicity. - Immunosuppressants (e.g., cyclosporine): monitor for enhanced infection susceptibility.