Medaxonum Lido

Ceftriaxone, the active antibiotic ingredient in Medaxonum Lido, is a third‑generation cephalosporin presented as an injection for intramuscular use. Combined with lidocaine hydrochloride, the product treats severe bacterial infections such as pneumonia, meningitis and intra‑abdominal infections, while providing local anesthesia for the injection itself.

GNH USA supplies Medaxonum Lido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Medaxonum Lido, containing ceftriaxone and lidocaine, is indicated for bacterial infections treated via systemic antibacterial activity and for providing local anesthesia during intramuscular injection.

- Pneumonia: effective bacterial clearance in community‑acquired or hospital‑acquired pneumonia. - Meningitis: rapid eradication of causative organisms in bacterial meningitis. - Intra‑abdominal infections: broad‑spectrum coverage for complicated intra‑abdominal sepsis. - Local anesthesia for intramuscular injection: lidocaine component reduces injection‑related pain.

Common Side Effects: - Injection site pain or erythema. - Diarrhoea or loose stools. - Nausea or mild vomiting. - Transient rash or pruritus. - Mild elevation of liver enzymes.

Serious or Rare Side Effects: - Anaphylactic or severe allergic reactions. - Clostridioides difficile‑associated colitis. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Seizures, particularly with high doses or renal impairment. - Hepatic dysfunction or jaundice.

Before using Medaxonum Lido, consider the following precautions: - Renal impairment: monitor renal function and adjust therapy as needed. - Hepatic dysfunction: observe liver enzymes during treatment. - Allergy to beta‑lactam antibiotics: avoid use in patients with known hypersensitivity. - Neonates and infants: use with caution due to altered pharmacokinetics. - Pregnancy Category B: prescribe only when clearly indicated. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Medaxonum Lido may interact with other medicines as follows:

Major Interactions (Avoid): - Calcium‑containing IV solutions: risk of insoluble precipitate formation. - Probenecid: can increase ceftriaxone plasma concentrations. - Warfarin: may potentiate anticoagulant effect and increase bleeding risk. - Live vaccines: concurrent use may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely): - Aminoglycosides: additive nephrotoxicity, monitor renal function. - Loop diuretics: increased risk of ototoxicity when combined with lidocaine. - Other central nervous system depressants: may enhance systemic lidocaine toxicity.