Mecolzine

Mesalazine, the active ingredient in Mecolzine, is an aminosalicylate presented as a rectal formulation for local use. It is employed to reduce inflammation in the intestinal lining of patients with ulcerative colitis and other inflammatory bowel diseases.

GNH USA supplies Mecolzine as a licensed, GDP‑compliant international pharmaceutical product, adhering to EU quality standards and providing reliable sourcing for hospitals, pharmacies and clinics worldwide. Our global logistics network ensures timely delivery and regulatory compliance across diverse markets, while maintaining strict traceability and product integrity.

Mecolzine (mesalazine) is used to treat inflammatory bowel disease by targeting colonic inflammation.

- Ulcerative colitis: induces remission and reduces symptoms such as bleeding and urgency. - Proctitis: delivers anti‑inflammatory effect directly to the rectal mucosa, alleviating irritation. - Maintenance therapy for IBD: helps sustain remission and prevent flare‑ups when used long‑term.

Mecolzine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Rectal irritation or burning sensation - Abdominal pain or cramping - Nausea or mild vomiting - Headache - Flatulence or bloating - Diarrhoea

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis, rash, swelling) - Blood in stool or severe gastrointestinal bleeding - Elevated liver enzymes or hepatic dysfunction - Pancreatitis - Severe colitis or perforation - Myocarditis or other cardiac inflammation

Before prescribing Mecolzine, clinicians should consider several safety aspects.

- Pregnancy: safety not established; use only if potential benefit justifies risk. - Breastfeeding: unknown; weigh benefits against possible infant exposure. - Renal impairment: monitor renal function and adjust therapy as needed. - Hepatic impairment: use with caution; periodic liver function tests recommended. - Active infection: avoid use in patients with severe infections until resolved. - Store at room temperature below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Mecolzine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Azathioprine: heightened risk of bone‑marrow suppression. - NSAIDs: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely): - Oral contraceptives: possible reduction in contraceptive efficacy. - Corticosteroids: potential for enhanced immunosuppression and infection risk.