Mecolzine

Mesalazine, the active ingredient in Mecolzine, is a 5-aminosalicylic acid (5-ASA) presented as a rectal formulation for local administration. It is used to reduce inflammation in the colon, specifically targeting ulcerative colitis limited to the rectum (proctitis) and other forms of inflammatory bowel disease in adult patients.

GNH USA supplies Mecolzine as a licensed, GDP-compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide with adherence to EU quality standards. Our distribution network ensures reliable delivery and regulatory compliance for each shipment.

Mecolzine (mesalazine) is employed in the management of inflammatory bowel disease, acting locally on the colonic mucosa.

- Ulcerative colitis (proctitis): reduces rectal inflammation and promotes mucosal healing. - Ulcerative colitis (left‑sided colitis): delivers targeted anti‑inflammatory effect to the distal colon. - Inflammatory bowel disease (distal colitis): provides local control of inflammation in the affected segment.

Mecolzine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Rectal irritation or burning sensation. - Abdominal pain or cramping. - Nausea or mild vomiting. - Headache. - Flatulence. - Diarrhoea.

Serious or Rare Side Effects: - Allergic reaction (rash, itching, swelling). - Severe colitis with blood in stool. - Hepatic enzyme elevation. - Pancreatitis. - Acute kidney injury. - Severe hypersensitivity (anaphylaxis).

Before using Mecolzine, consider the following safety measures.

- Pregnancy: safety not established; use only if potential benefit justifies the risk. - Breastfeeding: unknown safety; evaluate risk versus benefit. - Renal impairment: monitor kidney function regularly. - Hepatic impairment: use with caution and observe liver enzymes. - Concomitant NSAIDs: may increase renal toxicity; monitor renal parameters. - Store at room temperature: keep in the original packaging, protect from moisture and light.

Mecolzine can interact with several medicines; awareness helps avoid complications.

Major Interactions (Avoid): - Azathioprine: increased risk of bone‑marrow suppression. - Methotrexate: additive toxicity to liver and bone marrow. - Anticoagulants (e.g., warfarin): may enhance bleeding tendency.

Moderate Interactions (Monitor Closely): - Oral contraceptives: mesalazine may reduce hormonal efficacy. - NSAIDs: combined use can raise the risk of renal impairment.