Mecastrin (Melatonin)

Melatonin, the active ingredient in Mecastrin, is a melatonin receptor agonist presented as an oral formulation for oral use. It is used to support the regulation of sleep patterns and is indicated for individuals experiencing difficulty initiating or maintaining sleep.

GNH USA supplies Mecastrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mecastrin is a melatonin receptor agonist that acts on the sleep‑wake regulatory system. - Insomnia: helps reduce sleep onset latency and improve sleep continuity. - Sleep‑wake rhythm disorders: assists in synchronising circadian rhythms in shift‑work or jet‑lag situations. - Delayed sleep phase syndrome: facilitates earlier sleep onset by advancing circadian timing.

Mecastrin may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Drowsiness or daytime sleepiness - Headache - Dizziness - Nausea - Vivid dreams or nightmares

Serious or Rare Side Effects: - Allergic reactions (rash, itching, swelling) - Mood changes (depression, anxiety) - Hormonal effects (menstrual irregularities) - Severe hypotension (very low blood pressure)

Before using Mecastrin, consider the following safety measures. - Pregnancy: consult a healthcare professional as safety data are limited. - Breastfeeding: discuss potential exposure with a physician. - Pediatric use: use only under medical supervision. - Concomitant CNS depressants: monitor for additive sedation. - Anticoagulant therapy: observe for altered bleeding risk. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Mecastrin can interact with several medication classes; awareness helps minimise risk.

Major Interactions (Avoid): - Warfarin or other anticoagulants: may increase bleeding tendency. - Cyclosporine: potential alteration of drug levels. - Estrogen‑containing contraceptives: possible reduction in efficacy.

Moderate Interactions (Monitor Closely): - Sedative agents (benzodiazepines, antihistamines): may enhance drowsiness. - Antihypertensives: could cause additive blood pressure lowering. - Antidiabetic drugs: monitor blood glucose as melatonin may affect glycaemic control.