Maxon

Sildenafil, the active ingredient in Maxon, is a phosphodiesterase type 5 inhibitor (PDE5 inhibitor) presented as an oral tablet for oral use. It treats erectile dysfunction and pulmonary arterial hypertension in adult patients. GNH USA supplies Maxon as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Sildenafil acts on the nitric‑oxide/cGMP pathway to improve vascular smooth‑muscle relaxation in specific conditions.

- Erectile dysfunction: facilitates erection by increasing blood flow to the corpus cavernosum, helping men achieve and sustain sufficient rigidity for satisfactory sexual performance. - Pulmonary arterial hypertension: causes pulmonary vasodilation, lowering arterial pressure and improving exercise tolerance in patients with this chronic lung vascular condition. - Raynaud's phenomenon (off‑label): may reduce the frequency of vasospastic attacks by enhancing peripheral blood flow.

Common Side Effects: - Headache - Facial flushing - Indigestion or dyspepsia - Nasal congestion - Visual disturbances (e.g., blurred vision, blue‑tinted vision) - Back or muscle pain

Serious or Rare Side Effects: - Priapism (prolonged erection lasting more than 4 hours) - Sudden loss of vision (non‑arteritic anterior ischemic optic neuropathy) - Sudden hearing loss or tinnitus - Cardiovascular events such as myocardial infarction or stroke - Severe hypotension, especially when combined with nitrates

Before initiating therapy, patients should be evaluated for cardiovascular health and contraindications.

- Medical evaluation: assess cardiovascular status and underlying heart conditions. - Nitrate use: avoid concurrent use with nitrates or nitric‑oxide donors due to risk of severe hypotension. - Retinal disorders: use with caution in patients with retinitis pigmentosa or other retinal diseases. - Alcohol consumption: limit excessive alcohol as it may increase the likelihood of side effects. - Store at room temperature below 25°C: keep in the original packaging, protect from moisture and light.

Sildenafil may interact with several medication classes, requiring careful review.

Major Interactions (Avoid): - Nitrates (e.g., nitroglycerin, isosorbide dinitrate): can cause dangerous drops in blood pressure. - Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir): increase sildenafil plasma levels. - Guanylate cyclase stimulators (e.g., riociguat): may lead to additive hypotensive effects. - Alpha‑blockers (certain formulations): risk of marked hypotension.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy. - Antihypertensive agents: monitor blood pressure for additive effects. - Protease inhibitors (e.g., saquinavir): may modestly increase sildenafil exposure. - Diuretics: watch for orthostatic hypotension. - Other PDE5 inhibitors: avoid concurrent use to prevent overdose.