Maxartan

Losartan potassium, the active ingredient in Maxartan, is an angiotensin II receptor blocker presented as a tablet for oral use. It is combined with hydrochlorothiazide, a thiazide diuretic, to treat hypertension in adult patients. It helps lower blood pressure by blocking the effects of angiotensin II and reducing fluid retention, offering a synergistic approach for patients requiring combined therapy.

GNH USA supplies Maxartan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Maxartan, a combination of an angiotensin II receptor blocker and a thiazide diuretic, is used to manage hypertension and related conditions.

- Hypertension: lowers systolic and diastolic blood pressure in patients with primary hypertension. - Hypertension with fluid retention: provides additional diuretic effect to reduce excess extracellular fluid. - Hypertension in patients requiring combined therapy: offers convenient single‑tablet regimen for those needing both an ARB and a thiazide diuretic.

Common Side Effects: - Dizziness or light‑headedness. - Headache. - Increased urination. - Electrolyte disturbances such as low potassium. - Mild fatigue.

Serious or Rare Side Effects: - Severe allergic reactions (e.g., rash, swelling, difficulty breathing). - Acute kidney injury or worsening renal function. - Significant hypotension leading to fainting. - Hyperkalemia, especially when used with potassium‑sparing agents. - Pancreatitis (rare).

Before initiating therapy, patients should be evaluated for renal function, electrolyte balance, and blood pressure control.

- Monitor blood pressure: ensure adequate reduction without excessive hypotension. - Assess renal function: check serum creatinine and eGFR regularly. - Check electrolytes: especially potassium and sodium levels. - Use caution in severe liver disease: dose adjustments may be required. - Elderly patients: start at lower doses and monitor for orthostatic effects. - Store at below 25°C: keep in the original pack, protect from moisture.

Maxartan may interact with several medicines that affect blood pressure, renal function, or electrolyte balance.

Major Interactions (Avoid): - ACE inhibitors or aliskiren: risk of additive hyperkalemia and renal impairment. - Potassium supplements or potassium‑sparing diuretics: may cause dangerous hyperkalemia. - NSAIDs (e.g., ibuprofen, naproxen): can blunt antihypertensive effect and affect kidney function. - Lithium: increased lithium levels and toxicity. - Dual renin‑angiotensin system blockade: heightened risk of adverse renal outcomes.

Moderate Interactions (Monitor Closely): - Other diuretics: may exacerbate electrolyte disturbances. - Antidiabetic agents: enhanced hypoglycemic effect. - Rifampin or other CYP inducers: may reduce losartan plasma concentrations. - Beta‑blockers: additive blood‑pressure lowering effect. - CYP2C9 inhibitors (e.g., fluconazole): may increase losartan levels.