Matepil

Quetiapine, the active ingredient in Matepil, is a atypical antipsychotic presented as a oral tablet for oral use. It treats schizophrenia, bipolar disorder (both manic and depressive phases) and is used as an adjunct in major depressive disorder in adult patients.

GNH USA supplies Matepil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Quetiapine is an atypical antipsychotic used to manage several psychiatric conditions.

- Schizophrenia: reduces psychotic symptoms and lowers relapse risk. - Bipolar disorder (manic episodes): stabilises mood and prevents mania. - Bipolar disorder (depressive episodes): alleviates depressive symptoms. - Adjunct treatment of major depressive disorder: enhances response to primary antidepressants.

Quetiapine may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Sedation or somnolence. - Dizziness, especially on standing. - Dry mouth. - Constipation. - Weight gain. - Orthostatic hypotension.

Serious or Rare Side Effects: - Agranulocytosis. - Neuroleptic malignant syndrome. - Tardive dyskinesia. - Suicidal thoughts or behaviours. - Severe hypotension or cardiac arrhythmia. - Hepatic dysfunction.

When prescribing quetiapine, clinicians should consider several safety measures.

- Monitor metabolic parameters: weight, glucose and lipid levels. - Assess for suicidal ideation, especially early in treatment. - Evaluate cardiovascular status: risk of orthostatic hypotension. - Use caution in elderly patients due to increased fall risk. - Store at room temperature: keep in the original pack, protect from moisture and light.

Quetiapine can interact with other medicines, requiring attention to avoid reduced efficacy or heightened toxicity.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase quetiapine plasma levels. - Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce quetiapine effectiveness. - Concurrent CNS depressants (e.g., benzodiazepines, alcohol): can enhance sedation and respiratory depression.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: may potentiate orthostatic hypotension. - Anticholinergic drugs: can worsen dry mouth and constipation. - Lithium: may increase risk of neurotoxicity.