Mastoprofen

Progesterone, the active ingredient in Mastoprofen, is a progestogen presented as a topical formulation for dermal use. It is employed in hormone therapy to support reproductive tissue function and maintain hormonal balance.

GNH USA supplies Mastoprofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mastoprofen (progesterone) is used in hormone‑related conditions where progesterone activity is required.

Menopausal hormone therapy: helps alleviate vasomotor symptoms and provides endometrial protection. Luteal phase support: supplies progesterone to sustain early pregnancy in assisted reproductive cycles. Premenstrual syndrome: reduces mood swings, breast tenderness and other cyclic discomforts.

Progesterone applied topically can cause a range of reactions, most of which are mild and reversible.

Common Side Effects: - Skin irritation or redness at the application site - Itching or mild rash - Breast tenderness or swelling - Headache - Nausea or mild gastrointestinal upset - Fatigue or drowsiness

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis, angioedema) - Extensive skin blistering or necrosis - Thromboembolic events (deep vein thrombosis, pulmonary embolism) - Hepatic enzyme abnormalities - Adrenal insufficiency with prolonged use - Unexplained vaginal bleeding

When using Mastoprofen, consider the following safety measures.

Pregnancy: use only under direct medical supervision, as progesterone may affect fetal development. Breastfeeding: consult a healthcare professional before application. Hormone‑sensitive conditions: avoid if you have a history of estrogen‑dependent tumors. Drug interactions: review all concomitant medications with your prescriber. Skin integrity: do not apply to broken, infected, or inflamed skin. Store at ambient temperature: keep in the original container, protect from moisture and direct light.

Progesterone can interact with several medicines; categorize the risk level.

Major Interactions (Avoid): - Combined oral contraceptives: may increase thromboembolic risk. - Antifungal azoles (e.g., ketoconazole): can raise systemic progesterone levels. - Strong CYP3A4 inhibitors (e.g., itraconazole): may elevate exposure and side‑effect potential.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampicin): may reduce progesterone effectiveness. - Anticoagulants (e.g., warfarin): progesterone may enhance anticoagulant effect. - Glucocorticoids: concurrent use may alter hormonal balance and require monitoring.