Markoton (Heparin Sodium, Dexpanthenol)

Heparin Sodium, the active ingredient in Markoton, is an anticoagulant presented as a topical formulation for skin application. It, together with Dexpanthenol, is used to prevent superficial thrombosis and to support skin protection and wound healing.

GNH USA supplies Markoton as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Markoton combines an anticoagulant and a skin‑repair agent, acting on the coagulation cascade and epidermal barrier.

- Prevention of superficial thrombosis: reduces clot formation in superficial veins. - Skin protection: helps maintain barrier integrity after minor injuries. - Wound healing: promotes tissue repair and reduces inflammation.

Common Side Effects: - Local erythema: mild redness at the application site. - Itching: transient pruritus. - Dryness: temporary skin dryness. - Burning sensation: mild transient burning. - Contact dermatitis: mild allergic reaction.

Serious or Rare Side Effects: - Severe allergic reaction: anaphylaxis. - Extensive skin necrosis: rare but serious tissue damage. - Bleeding complications: systemic absorption leading to abnormal bleeding.

Markoton should be used with caution in specific situations. - Avoid use on open wounds: limit to intact skin or as directed. - Do not apply over large surface areas: limit to prescribed area to reduce systemic absorption. - Monitor for signs of bleeding: especially if patient uses other anticoagulants. - Pregnancy and lactation: use only if clearly needed. - Store at room temperature below 25°C: keep in the original container, protect from moisture and light.

Markoton may interact with other medicines that affect coagulation or skin absorption.

Major Interactions (Avoid): - Concurrent systemic anticoagulants (e.g., warfarin, direct oral anticoagulants): increased bleeding risk. - Heparin‑induced thrombocytopenia antibodies: may exacerbate the condition.

Moderate Interactions (Monitor Closely): - Topical corticosteroids: may alter skin absorption. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): additive bleeding risk. - Antiplatelet agents (e.g., aspirin, clopidogrel): monitor for bruising.