Marevan

Warfarin Sodium, the active ingredient in Marevan, is a vitamin K antagonist presented as an oral tablet for oral use. It is used to prevent and treat thromboembolic disorders in adult patients.

GNH USA supplies Marevan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Marevan is a vitamin K antagonist used in the management of various thromboembolic conditions. - Atrial fibrillation: reduces the risk of stroke by inhibiting clot formation. - Deep vein thrombosis: treats existing clots and prevents recurrence. - Pulmonary embolism: facilitates resolution of emboli and prevents new events. - Stroke prophylaxis: lowers incidence of ischemic stroke in high‑risk patients.

Adverse reactions may occur with any anticoagulant therapy and should be monitored.

Common Side Effects: - Bruising or minor bleeding. - Nosebleeds. - Bleeding gums. - Blood in urine or stool. - Headache. - Dizziness.

Serious or Rare Side Effects: - Severe or uncontrolled bleeding. - Hemorrhagic stroke. - Skin necrosis. - Allergic reactions such as rash or angioedema. - Liver dysfunction. - Unexplained drop in hemoglobin.

Warfarin therapy requires careful monitoring and patient education. - Monitor INR: regular blood tests are needed to keep INR within the therapeutic range. - Adjust diet: consistent intake of vitamin K‑containing foods helps maintain stable anticoagulation. - Review medications: many drugs can alter warfarin effect; inform healthcare providers of all medicines. - Pregnancy contraindication: warfarin is classified as Pregnancy Category X and should not be used. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Warfarin has numerous drug and food interactions that can affect its anticoagulant effect.

Major Interactions (Avoid): - Macrolide antibiotics (e.g., erythromycin): increase warfarin plasma levels. - Fluoroquinolone antibiotics (e.g., ciprofloxacin): potentiate anticoagulant effect. - Amiodarone: raises warfarin concentration. - NSAIDs (e.g., ibuprofen): heighten bleeding risk.

Moderate Interactions (Monitor Closely): - Antiplatelet agents (e.g., clopidogrel): additive bleeding risk. - Herbal supplements (e.g., ginkgo, garlic): may alter INR. - Thyroid hormone therapy: can modify warfarin metabolism.