Mantomed

Memantine Hydrochloride, the active ingredient in Mantomed, is a NMDA receptor antagonist presented as an oral tablet for oral use. It is used to treat moderate to severe Alzheimer’s disease in adults.

GNH USA supplies Mantomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Memantine is an NMDA‑receptor antagonist indicated for the treatment of Alzheimer’s disease, a neurodegenerative disorder affecting cognition and function.

Alzheimer’s disease (moderate to severe): helps maintain cognitive abilities and daily functioning in patients with established disease.

Memantine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Dizziness - Headache - Constipation - Fatigue - Confusion - Hypertension

Serious or Rare Side Effects: - Seizures - Severe allergic reaction (anaphylaxis) - Hallucinations or psychosis - Cardiac arrhythmia - Suicidal thoughts or behavior

Before initiating therapy, consider patient‑specific factors and monitor for adverse events. - Renal impairment: adjust dose or avoid if severe. - History of seizures: monitor closely for increased seizure activity. - Concomitant use of other NMDA antagonists: avoid due to additive neurotoxicity. - Cardiovascular disease: monitor blood pressure and heart rate. - Pregnancy or breastfeeding: use only if potential benefit justifies potential risk. - Store at room temperature: keep in the original container, protect from moisture and light.

Memantine can interact with several drug classes, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid): - Amantadine: may increase neurotoxic risk. - Other NMDA‑receptor antagonists (e.g., ketamine): additive central nervous system effects. - Strong CYP3A4 inducers: may lower memantine plasma concentrations.

Moderate Interactions (Monitor Closely): - CNS depressants (e.g., benzodiazepines): enhanced sedation. - Diuretics: may raise memantine levels. - Antihypertensives: potential additive blood‑pressure lowering.