GNH USA

Europe — EMA

Mantomed

GNH USA supplies Mantomed (Memantine Hydrochloride), a NMDA receptor antagonist for moderate to severe Alzheimer’s disease. Request a quote for global supply.

Memantine Hydrochloride

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What is Memantine Hydrochloride?

Memantine Hydrochloride, the active ingredient in Mantomed, is a NMDA receptor antagonist presented as a tablet for oral use. It is indicated for the treatment of moderate to severe Alzheimer’s disease in adult patients, helping to reduce neuro‑excitotoxic damage.

GNH USA supplies Mantomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and research institutions worldwide.

What is Memantine Hydrochloride used for?

Memantine Hydrochloride acts on the glutamatergic pathway implicated in Alzheimer’s disease, providing symptomatic benefit in cognitive function.

Alzheimer’s disease (moderate to severe): improves cognition, daily functioning, and may slow progression of neuro‑degeneration.

What are the side effects of Memantine Hydrochloride?

Adverse reactions reported with memantine may vary in frequency and severity.

Common Side Effects: - Dizziness: transient light‑headedness - Headache: mild to moderate intensity - Constipation: reduced bowel movements - Confusion: occasional disorientation

Serious or Rare Side Effects: - Seizures: new onset or worsening - Cardiac arrhythmia: irregular heartbeat - Severe allergic reaction: rash, swelling, anaphylaxis

What precautions apply to Memantine Hydrochloride?

When prescribing memantine, clinicians should consider several safety aspects.

Renal impairment: dose may need adjustment and renal function should be monitored Hepatic impairment: monitor liver enzymes and consider dose modification History of seizures: use with caution as memantine may lower seizure threshold Concurrent use of other NMDA antagonists: avoid due to additive effects Pregnancy and lactation: safety not established; weigh potential risks and benefits Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture and light

What does Memantine Hydrochloride interact with?

Memantine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid): - Concomitant use with high‑dose amantadine: may increase neurotoxicity - Potassium channel blockers (e.g., amiodarone): risk of cardiac effects - Strong CYP3A4 inducers (e.g., rifampicin): may reduce memantine levels

Moderate Interactions (Monitor Closely): - Anticholinergic agents: may diminish cognitive benefit - CNS depressants (e.g., benzodiazepines): enhanced sedation

Frequently asked questions

What is Mantomed used for?+
Mantomed contains memantine hydrochloride and is prescribed for the symptomatic treatment of moderate to severe Alzheimer’s disease in adult patients. It helps improve cognition, daily functioning, and may slow disease progression by reducing excitotoxic neuronal damage.
How does Memantine Hydrochloride work?+
Memantine hydrochloride acts as a non‑competitive antagonist at the NMDA receptor. By blocking excessive calcium influx caused by overstimulation with glutamate, it reduces excitotoxicity while allowing normal neurotransmission, which supports neuronal survival in Alzheimer’s disease.
What is the usual dose of Mantomed?+
The dosage of Mantomed is individualized by the prescribing clinician based on the patient’s condition, renal function, and tolerability. No fixed regimen is provided here; the prescriber determines the appropriate dose and titration schedule.
Is Mantomed safe in pregnancy or breastfeeding?+
Safety data for memantine during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Use only if the potential benefit justifies the potential risk to the fetus or infant, and discuss with a healthcare professional.
How do I order Mantomed from GNH USA?+
To request Mantomed, submit an enquiry on the product page at gnh-usa.com with the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mantomed compare with the main alternative drug or class?+
The primary alternative class for Alzheimer’s disease is acetylcholinesterase inhibitors such as donepezil. While those agents increase acetylcholine levels, memantine (Mantomed) modulates glutamate activity. Both can be used together for complementary effects, but their mechanisms, side‑effect profiles, and contraindications differ.
How should Mantomed be stored and handled?+
Mantomed tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use after the expiry date printed on the packaging.
How is Mantomed administered?+
Mantomed is taken orally, usually once daily after a gradual titration period as directed by the prescriber. Tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed.
What are the most serious risks to watch for while taking Mantomed?+
Serious risks include the possibility of seizures, cardiac arrhythmias, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience unexplained convulsions, irregular heartbeats, or signs of a severe hypersensitivity reaction.
Who should not use Mantomed?+
Mantomed is contraindicated in patients with known hypersensitivity to memantine or any tablet excipients. Caution is advised for individuals with uncontrolled seizures, severe renal or hepatic impairment, and those taking other NMDA antagonists. Pregnant or breastfeeding women should only use it when clearly indicated by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Memantine Hydrochloride
Route
Oral Use
Manufacturer
Medochemie Ltd.
Origin
EU

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