Mannitol, Viaflo Baxter

Mannitol, the active ingredient in Mannitol, Viaflo Baxter, is a osmotic diuretic presented as a solution for injection for intravenous use. It reduces intracranial and intraocular pressure and promotes diuresis in acute renal failure.

GNH USA supplies Mannitol, Viaflo Baxter as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Mannitol is an osmotic diuretic used in conditions where reduction of fluid pressure is required.

- Intracranial pressure: lowers pressure to protect brain tissue. - Cerebral edema: decreases brain swelling and improves neurological outcomes. - Acute renal failure: promotes diuresis to aid renal clearance. - Intraocular pressure: reduces pressure to help manage glaucoma and ocular emergencies.

Mannitol may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Headache: mild to moderate discomfort. - Nausea or vomiting: gastrointestinal upset. - Electrolyte imbalance: especially hyponatremia or hyperkalemia. - Hypotension: transient drop in blood pressure. - Tachycardia: increased heart rate.

Serious or Rare Side Effects: - Pulmonary edema: fluid accumulation in lungs. - Severe dehydration: excessive fluid loss. - Anaphylactic reaction: rare hypersensitivity. - Acute renal failure worsening: in patients with pre‑existing kidney impairment. - Cardiac arrhythmias: due to electrolyte disturbances.

When using Mannitol, clinicians should observe several safety measures.

- Renal function monitoring: assess creatinine and urine output. - Electrolyte surveillance: check serum sodium, potassium, and osmolality. - Fluid balance assessment: avoid over‑ or under‑hydration. - Cardiovascular status: use cautiously in heart failure or hypotension. - Intracranial lesions: evaluate risk of rapid pressure shifts. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Mannitol can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Loop diuretics: may cause excessive diuresis and electrolyte loss. - Insulin: can alter glucose control when fluid shifts occur. - Lithium: increased risk of lithium toxicity. - ACE inhibitors: heightened hypotensive effect.

Moderate Interactions (Monitor Closely): - Antihypertensives: additive blood pressure lowering. - NSAIDs: may impair renal clearance. - Corticosteroids: can exacerbate fluid retention. - Anticonvulsants: monitor for altered serum levels.