Mannitol Fresenius Kabi

Mannitol, the active ingredient in Mannitol Fresenius Kabi, is an osmotic diuretic presented as a sterile solution for injection for intravenous administration. By increasing extracellular osmolarity, it draws water from intracellular and interstitial compartments, thereby reducing intracranial pressure, treating cerebral edema, and promoting diuresis in patients with acute renal failure.

GNH USA supplies Mannitol Fresenius Kabi as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, transplant centres, oncology centres, pharmacies and clinics across global markets, ensuring consistent quality and regulatory compliance.

Mannitol is used as an osmotic diuretic to manage conditions associated with elevated intracranial, intraocular or renal fluid overload.

- Intracranial pressure elevation: reduces pressure by drawing fluid from brain tissue, helping to control cerebral edema. - Cerebral edema: lowers brain swelling by osmotic fluid shift, improving neurological outcomes. - Acute renal failure (oliguric phase): promotes diuresis to facilitate fluid removal when kidney function is impaired. - Intraocular pressure increase: decreases ocular pressure by extracting fluid from the vitreous body.

Common Side Effects: - Headache: mild to moderate discomfort often related to rapid fluid shifts. - Nausea: transient feeling of queasiness during infusion. - Vomiting: occasional emesis, especially with higher infusion rates. - Electrolyte imbalance (hypokalemia): reduced serum potassium due to diuresis.

Serious or Rare Side Effects: - Worsening renal failure: excessive diuresis may impair remaining kidney function. - Severe allergic reaction (anaphylaxis): rare but can be life‑threatening. - Pulmonary edema: fluid overload if infusion is too rapid. - Significant electrolyte disturbances: severe hyponatremia or hypernatremia.

Mannitol should be used with careful clinical monitoring and appropriate patient selection. - Assess renal function: evaluate creatinine clearance before initiating therapy. - Monitor serum electrolytes: check potassium, sodium and osmolarity regularly. - Use caution in heart failure: avoid fluid shifts that may exacerbate cardiac overload. - Avoid rapid infusion: administer at recommended rates to reduce risk of hypotension. - Adjust dose in pregnancy: consider fetal risk and maternal benefit, as category C. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the solution.

Mannitol may interact with other medications that affect fluid balance or renal function.

Major Interactions (Avoid): - Loop diuretics: additive diuretic effect can lead to severe electrolyte loss. - ACE inhibitors: combined use may cause marked hypotension. - Lithium: increased lithium toxicity due to altered renal clearance.

Moderate Interactions (Monitor Closely): - NSAIDs: may reduce the diuretic efficacy of Mannitol. - Aminoglycosides: concurrent use can increase risk of nephrotoxicity.