Mannitol Burg Pharma

Mannitol, the active ingredient in Mannitol Burg Pharma, is an osmotic diuretic presented as a solution for injection for intravenous use. It reduces intracranial and intraocular pressure and promotes diuresis in acute kidney injury and oliguric renal failure.

GNH USA supplies Mannitol Burg Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Mannitol is used in clinical settings to manage conditions where osmotic fluid shifts are therapeutic.

- Intracranial hypertension: lowers intracranial pressure by drawing water from brain tissue into the vascular compartment. - Intraocular hypertension: reduces intraocular pressure by osmotic dehydration of the vitreous humor. - Acute kidney injury: provides renal protection by increasing urine output and flushing tubular debris. - Oliguric renal failure: induces diuresis to improve fluid balance in patients with low urine output.

Mannitol may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Headache: mild to moderate pain often occurring shortly after infusion. - Nausea: sensation of unease that may lead to vomiting. - Vomiting: expulsion of stomach contents, usually transient. - Electrolyte imbalance (hypernatremia): elevated serum sodium levels. - Hypotension: drop in blood pressure, especially with rapid infusion. - Flushing: warmth and reddening of the skin.

Serious or Rare Side Effects: - Pulmonary edema: accumulation of fluid in the lungs, potentially compromising breathing. - Severe hypernatremia or hyponatremia: extreme shifts in sodium concentration that can affect neurological function. - Acute renal failure: sudden loss of kidney function. - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Seizures: uncontrolled electrical activity in the brain.

When using Mannitol, several precautions should be observed to ensure patient safety.

- Renal function: monitor serum electrolytes and urine output regularly. - Cardiovascular status: avoid rapid infusion in patients with heart failure or compromised circulation. - Pregnancy: use only if potential benefits justify potential risks to the fetus. - Concomitant diuretics: adjust fluid management to prevent excessive volume loss. - Hypersensitivity: discontinue immediately if signs of allergic reaction appear. - Store at 2-8 °C: keep refrigerated, protect from light, do not freeze or shake.

Mannitol can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - Loop diuretics: additive diuretic effect may cause severe electrolyte depletion. - Insulin: hyperosmolar state can impair glucose control, risking hyperglycemia. - Nephrotoxic agents (e.g., aminoglycosides, contrast media): increased risk of renal injury.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may enhance hypotensive response. - Antihypertensive agents: additive blood pressure lowering. - Lithium: altered renal clearance may increase lithium levels.