Mannitol Βιοσερ

Mannitol, the active ingredient in Mannitol Βιοσερ, is an osmotic diuretic presented as a solution for injection for intravenous use. It reduces intracranial pressure and promotes diuresis in patients with renal failure or ocular hypertension.

GNH USA supplies Mannitol Βιοσερ as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Mannitol is an osmotic diuretic used in conditions where reduction of fluid volume or pressure is required.

- Reduction of intracranial pressure: lowers cerebral edema and intracranial pressure in traumatic brain injury or neurosurgical patients. - Oliguric renal failure: increases urine output to manage acute kidney injury with low urine output. - Intraocular pressure elevation: facilitates aqueous humor outflow to lower intraocular pressure during ocular surgery.

Mannitol may cause a range of adverse reactions, from mild to severe, depending on patient factors and dosage.

Common Side Effects: - Headache: mild to moderate pain often reported during infusion. - Nausea and vomiting: gastrointestinal upset occurring shortly after administration. - Dizziness or light‑headedness: related to rapid plasma volume shifts. - Thirst or dry mouth: due to osmotic water movement. - Electrolyte imbalance: mild changes in sodium or potassium levels.

Serious or Rare Side Effects: - Pulmonary edema: fluid accumulation in the lungs, especially in patients with cardiac dysfunction. - Severe electrolyte disturbances: hypernatremia, hyperkalemia, or profound hyponatremia. - Worsening renal failure: especially in patients with pre‑existing kidney impairment. - Anaphylactic or severe allergic reaction: rare but requires immediate medical attention. - Hemolysis: rare destruction of red blood cells. - Cardiac arrhythmia: associated with electrolyte shifts.

Before initiating Mannitol therapy, clinicians should evaluate patient-specific risk factors and monitor relevant parameters.

- Assess renal function: evaluate baseline creatinine and urine output before administration. - Monitor electrolytes: check serum sodium, potassium, and osmolality during therapy. - Avoid in severe dehydration: ensure adequate volume status to prevent hypotension. - Use cautiously in heart failure: risk of fluid overload and pulmonary edema. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Mannitol can interact with several drug classes, requiring attention to avoid additive or harmful effects.

Major Interactions (Avoid): - Loop diuretics: additive diuretic effect may cause severe electrolyte loss. - Insulin: hyperosmolarity may potentiate hypoglycemia. - Lithium: increased risk of lithium toxicity due to altered renal clearance. - ACE inhibitors/ARBs: may exacerbate renal impairment when combined.

Moderate Interactions (Monitor Closely): - Antihypertensives: may enhance blood pressure lowering. - Nephrotoxic antibiotics (e.g., aminoglycosides): monitor renal function closely. - Contrast media: increased risk of renal dysfunction when used together.