GNH USA

Europe — EMA

Mandanol Plus (Paracetamol, Caffeine)

GNH USA supplies Mandanol Plus (Paracetamol and Caffeine), a analgesic and antipyretic for headache, fever and mild to moderate pain.

Paracetamol, Caffeine

Request sourcing

1
Pack/s

What is Paracetamol, Caffeine?

Paracetamol, the active ingredient in Mandanol Plus, is an analgesic and antipyretic presented as a tablet for oral use, combined with caffeine to enhance pain relief. It provides relief of mild to moderate pain and reduces fever in adults and children.

GNH USA supplies Mandanol Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Paracetamol, Caffeine used for?

Mandanol Plus, containing paracetamol and caffeine, is used to manage pain and fever through central analgesic and antipyretic mechanisms.

Headache: reduces pain and associated discomfort. Fever: lowers elevated body temperature. Mild to moderate pain: provides analgesic relief for conditions such as musculoskeletal aches, dental pain, or menstrual cramps.

What are the side effects of Paracetamol, Caffeine?

Mandanol Plus may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Nausea or upset stomach. - Headache or dizziness. - Insomnia or restlessness. - Increased heart rate. - Mild skin rash. - Gastro‑intestinal discomfort.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) with swelling, breathing difficulty. - Hepatotoxicity, especially with overdose or pre‑existing liver disease. - Blood disorders such as thrombocytopenia. - Severe skin reactions (Stevens‑Johnson syndrome, toxic epidermal necrolysis).

What precautions apply to Paracetamol, Caffeine?

Before using Mandanol Plus, consider the following safety measures.

Pregnancy: consult a healthcare professional before use. Liver disease: avoid or use only under medical supervision. Alcohol consumption: limit intake to reduce liver risk. Allergy: discontinue if signs of hypersensitivity appear. Overdose: seek immediate medical attention if excessive dose is suspected. Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

What does Paracetamol, Caffeine interact with?

Mandanol Plus can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid): - Alcohol: increased risk of liver toxicity. - Warfarin: may enhance anticoagulant effect, raising bleeding risk. - Other paracetamol‑containing products: risk of cumulative overdose.

Moderate Interactions (Monitor Closely): - Caffeine‑rich beverages or supplements: may amplify stimulant effects. - Antiepileptic drugs (e.g., carbamazepine, phenytoin): may increase caffeine clearance, reducing efficacy. - Certain antidepressants (e.g., SSRIs): may modestly affect caffeine metabolism.

Frequently asked questions

What is Mandanol Plus used for?+
Mandanol Plus is an over‑the‑counter oral tablet that combines paracetamol and caffeine to relieve mild to moderate pain such as headaches, musculoskeletal aches, dental discomfort, and to reduce fever. The caffeine component enhances the analgesic effect of paracetamol, providing faster and more effective symptom control.
How does paracetamol work in Mandanol Plus?+
Paracetamol works by inhibiting central cyclooxygenase enzymes, which reduces the synthesis of prostaglandins involved in pain signaling and temperature regulation. This action provides analgesic (pain‑relieving) and antipyretic (fever‑reducing) effects. In Mandanol Plus, caffeine adds a non‑selective adenosine‑receptor blockade that amplifies the analgesic response.
What is the usual dose of Mandanol Plus?+
The appropriate dose of Mandanol Plus is determined by a qualified prescriber or according to the product labeling. Dosage may vary based on age, weight, clinical condition, and other medications. Patients should follow the specific instructions provided by their healthcare professional or the package insert.
Is Mandanol Plus safe during pregnancy or breastfeeding?+
Safety of Mandanol Plus in pregnancy or while breastfeeding has not been fully established. Women who are pregnant, planning pregnancy, or nursing should discuss potential risks and benefits with their healthcare provider before using the product.
How do I order Mandanol Plus from GNH USA?+
To place an order, submit an enquiry on the Mandanol Plus product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Mandanol Plus compare with plain paracetamol tablets?+
Mandanol Plus contains the same amount of paracetamol as standard tablets but adds caffeine, which can enhance analgesic efficacy and reduce the time to pain relief. This combination may be preferred for headache or fatigue‑related pain, whereas plain paracetamol lacks the stimulant component and may be chosen when caffeine is contraindicated.
What are the storage requirements for Mandanol Plus?+
Mandanol Plus should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, direct sunlight and excessive heat to maintain potency and stability.
How is Mandanol Plus administered?+
Mandanol Plus is taken orally with a glass of water. It is usually swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional. The tablet should be taken with or without food as tolerated.
What are the most serious risks associated with Mandanol Plus?+
The most serious risks include severe allergic reactions (anaphylaxis), hepatotoxicity from overdose or pre‑existing liver disease, and rare but serious skin conditions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Prompt medical attention is required if any of these symptoms develop.
Who should not use Mandanol Plus?+
Individuals with known hypersensitivity to paracetamol, caffeine, or any excipients in the tablet should avoid Mandanol Plus. Patients with severe liver impairment, uncontrolled hypertension, or those taking interacting medications such as warfarin or other paracetamol‑containing products should consult a healthcare professional before use.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Paracetamol, Caffeine
Route
Oral Use
Manufacturer
Crescent Pharma Limited
Origin
EU

Related products

Algik

Algik

Paracetamol, Caffeine

Laboratórios Azevedos - Indústria Farmacêutica, S.A.
EU
Algine

Algine

Paracetamol, Caffeine

Adelco Chromatourgia Athinon E Colocotronis Bros Sa
EU
Algofen Duofast

Algofen Duofast

Paracetamol, Caffeine

Medochemie Ltd.
EU
Algofen Duofast

Algofen Duofast

Paracetamol, Caffeine

Medochemie Ltd.
EU