GNH USA

Europe — EMA

Maicox

GNH USA supplies Maicox (Fluconazole), a triazole antifungal for candidiasis and cryptococcal meningitis for treatment. Request a quote for global supply.

Fluconazole

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What is Fluconazole?

Fluconazole, the active ingredient in Maicox, is a triazole antifungal presented as an unknown/unknown for oral use. It treats candidiasis, systemic candidiasis and cryptococcal meningitis in patients as prescribed.

GNH USA supplies Maicox as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

What is Fluconazole used for?

Fluconazole is a triazole antifungal that interferes with fungal cell membrane synthesis.

Candidiasis (oropharyngeal, esophageal, vaginal): eradicates Candida species and relieves infection symptoms. Systemic candidiasis: treats invasive Candida infections throughout the body. Cryptococcal meningitis: used as part of therapy to control fungal meningitis caused by Cryptococcus species.

What are the side effects of Fluconazole?

Fluconazole may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Headache: transient cranial discomfort. - Rash: skin redness or itching. - Diarrhea: loose stools.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or liver injury. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - QT prolongation: potential cardiac rhythm disturbances. - Anaphylaxis: rare severe allergic response. - Blood dyscrasias: neutropenia or thrombocytopenia.

What precautions apply to Fluconazole?

Before prescribing fluconazole, consider the following safety measures. - Renal or hepatic impairment: adjust dose as clinically indicated. - Concomitant azole therapy: avoid duplication to prevent excess exposure. - Pregnancy: use only if potential benefits outweigh risks. - Drug interactions: review all concomitant medications for possible interactions. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

What does Fluconazole interact with?

Fluconazole interacts with several medicines; monitoring is essential.

Major Interactions (Avoid): - Rifampin: markedly reduces fluconazole plasma concentrations. - Phenytoin: decreases fluconazole exposure, compromising efficacy. - Terbinafine: combined use increases risk of hepatotoxicity.

Moderate Interactions (Monitor Closely): - Warfarin: fluconazole may increase INR, requiring dose adjustment. - Cyclosporine: fluconazole can raise cyclosporine levels, necessitating monitoring. - Oral contraceptives: fluconazole may reduce hormonal effectiveness, advise backup contraception.

Frequently asked questions

What conditions is Maicox (fluconazole) used for?+
Maicox contains fluconazole, which is prescribed to treat infections caused by susceptible fungi, including oropharyngeal, esophageal and vaginal candidiasis, systemic (invasive) candidiasis, and cryptococcal meningitis. The medication is used when a clinician determines that an azole antifungal is appropriate for the specific infection.
How does fluconazole work to treat fungal infections?+
Fluconazole blocks the fungal enzyme 14α‑demethylase, a cytochrome P450 isoform needed to convert lanosterol into ergosterol. Without ergosterol, the fungal cell membrane becomes defective, leading to impaired growth or cell death. This mechanism targets a pathway that human cells do not rely on, providing selective antifungal activity.
What is the usual dose of Maicox (fluconazole)?+
The dosage of fluconazole is individualized by the prescribing healthcare professional based on the type and severity of the infection, patient age, renal and hepatic function, and other clinical factors. Patients should follow the exact regimen written on the prescription label and consult their prescriber for any clarification.
Is fluconazole safe to use during pregnancy or while breastfeeding?+
Fluconazole should be used in pregnancy only when the potential benefit justifies any potential risk to the fetus, as safety data are limited. For breastfeeding mothers, fluconazole does pass into breast milk in small amounts; clinicians usually weigh the benefits to the mother against possible exposure to the infant before recommending use.
How do I order Maicox from GNH USA?+
To request Maicox, visit the product page on gnh-usa.com, enter the desired quantity, and submit the enquiry form. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does fluconazole compare with other antifungal agents?+
Fluconazole belongs to the triazole class and offers oral administration, good bioavailability, and a relatively favorable safety profile compared with some older azoles. It is less potent against certain resistant fungi than newer agents like voriconazole or echinocandins, but its convenience and spectrum make it a first‑line choice for many Candida infections.
What are the recommended storage conditions for Maicox?+
Maicox should be stored at ambient temperature, below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.
How is Maicox administered to patients?+
Maicox is taken orally, usually with a glass of water. The tablet (or capsule, if applicable) may be swallowed with or without food, unless the prescribing information advises otherwise. Patients should not split, crush, or chew the dosage form unless specifically instructed by a healthcare professional.
What are the most serious risks associated with fluconazole therapy?+
Serious adverse events, although uncommon, include liver toxicity (hepatitis or hepatic failure), severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, cardiac arrhythmias due to QT prolongation, and rare cases of anaphylaxis. Patients should seek immediate medical attention if they notice jaundice, rash, fever, or cardiac symptoms.
Who should not take fluconazole (Maicox)?+
Fluconazole is contraindicated in individuals with a known hypersensitivity to fluconazole or any other azole antifungal. Patients taking medications that have a major interaction, such as certain systemic azoles, rifampin, or those with uncontrolled severe liver disease, should avoid use unless a prescriber determines it is safe.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Fluconazole
Route
Oral Use
Manufacturer
Genetic Spa
Origin
EU

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