Magnesia

Magnesium oxide, the active ingredient in Magnesia, is an antacid/laxative presented as an oral preparation for use by adults and children. It neutralises excess gastric hydrochloric acid and increases intestinal water content, providing relief from heartburn, acid indigestion and occasional constipation. The compound is minimally absorbed, acting locally within the gastrointestinal tract.

GNH USA supplies Magnesia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across EU and global markets.

Magnesia (magnesium oxide) is used to manage gastrointestinal conditions related to excess acid or reduced bowel motility. - Heartburn: provides rapid neutralisation of gastric acid to relieve burning sensation. - Acid indigestion: reduces acidity, easing discomfort after meals. - Occasional constipation: increases intestinal water, facilitating softer stools and bowel movement.

Magnesium oxide may cause a range of adverse reactions, most of which are related to its gastrointestinal activity.

Common Side Effects: - Diarrhoea: loose, watery stools occurring after ingestion. - Abdominal cramping: mild to moderate discomfort in the stomach area. - Flatulence: increased intestinal gas leading to bloating. - Nausea: feeling of sickness or urge to vomit.

Serious or Rare Side Effects: - Hypermagnesemia: elevated serum magnesium levels, potentially causing muscle weakness, low blood pressure, or cardiac arrhythmia. - Severe electrolyte imbalance: disturbances in calcium or potassium levels. - Allergic reaction: rash, itching, swelling, or difficulty breathing. - Persistent constipation: paradoxical worsening of bowel movements.

When using Magnesia, consider the following safety measures to minimise risks. - Dosage adjustment: follow prescriber instructions, especially in renal impairment. - Renal function: avoid or monitor use in patients with reduced kidney function. - Electrolyte monitoring: check serum magnesium and other electrolytes during prolonged therapy. - Drug interactions: review concomitant medications that may affect magnesium levels. - Pregnancy and lactation: use only if clearly needed and prescribed by a healthcare professional. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Magnesium oxide can affect the absorption or activity of several other medicines.

Major Interactions (Avoid): - Tetracycline antibiotics: magnesium chelates reduce absorption, making the antibiotic ineffective. - Fluoroquinolone antibiotics: concurrent use decreases fluoroquinolone bioavailability. - Bisphosphonates: magnesium interferes with oral bisphosphonate absorption.

Moderate Interactions (Monitor Closely): - Levothyroxine: magnesium may lower thyroid hormone absorption; separate dosing by at least 4 hours. - Digoxin: increased magnesium can enhance digoxin effects, requiring monitoring. - Calcium channel blockers: combined hypermagnesemia may potentiate cardiovascular effects.