GNH USA

Europe — EMA

Madopark (Benserazide Hydrochloride, Levodopa)

GNH USA supplies Madopark (Levodopa/Benserazide), an antiparkinson agent for Parkinson's disease and Parkinsonian syndrome. Request a quote for global supply.

Benserazide Hydrochloride, Levodopa

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What is Benserazide Hydrochloride, Levodopa?

Levodopa/Benserazide, the active ingredients in Madopark, is an antiparkinson agent presented as a tablet for oral use. It treats Parkinson's disease and related Parkinsonian syndromes in adult patients by restoring dopamine levels in the brain.

GNH USA supplies Madopark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides full regulatory documentation to support import and distribution in multiple markets. Madopark is sourced from EU‑approved manufacturers ensuring consistent potency and compliance with European pharmacopeial specifications.

What is Benserazide Hydrochloride, Levodopa used for?

Madopark, an antiparkinson agent, is indicated for several Parkinsonian conditions.

Parkinson's disease: improves motor function and reduces rigidity and bradykinesia. Parkinsonian syndrome: alleviates tremor, stiffness, and gait disturbances. Secondary Parkinsonism: helps control symptoms when caused by medication or other neurological disorders.

What are the side effects of Benserazide Hydrochloride, Levodopa?

Adverse reactions to Madopark vary in frequency and severity.

Common Side Effects: - Nausea - Orthostatic hypotension - Dizziness - Dry mouth

Serious or Rare Side Effects: - Dyskinesia - Hallucinations - Severe hypotension - Neuroleptic malignant‑like syndrome

What precautions apply to Benserazide Hydrochloride, Levodopa?

When prescribing Madopark, clinicians should consider several precautionary measures to ensure safe use.

Dose titration: start with a low dose and increase gradually to minimize side effects. Renal impairment: adjust dose as needed. Hepatic dysfunction: use with caution. Concomitant MAO‑B inhibitors: avoid within 14 days. Pregnancy and lactation: safety not established; use only if benefit outweighs risk. Store at ambient temperature: keep in original container, protect from moisture and light.

What does Benserazide Hydrochloride, Levodopa interact with?

Madopark can interact with other medicines; awareness of the interaction level helps guide monitoring.

Major Interactions (Avoid): - Non‑selective MAO inhibitors: may cause hypertensive crisis. - Anticholinergic drugs: may mask Parkinsonian symptoms. - High‑dose vitamin B6 (pyridoxine): reduces levodopa efficacy.

Moderate Interactions (Monitor Closely): - Selective MAO‑B inhibitors: may increase levodopa levels; monitor for dyskinesia. - Antihypertensive agents: additive hypotensive effect. - Iron supplements: decrease levodopa absorption; separate dosing by at least 2 hours.

Frequently asked questions

What is Madopark used for?+
Madopark is prescribed to manage motor symptoms of Parkinson's disease and related Parkinsonian syndromes. By increasing dopamine availability in the brain, it helps reduce tremor, rigidity, bradykinesia, and gait disturbances, improving overall functional ability in affected adults.
How does levodopa/benserazide work?+
Levodopa serves as a precursor that is converted to dopamine once it crosses the blood‑brain barrier. Benserazide inhibits the peripheral enzyme dopa‑decarboxylase, preventing levodopa from being transformed outside the brain. This combination maximizes central dopamine production while limiting peripheral side effects.
What is the usual dose of Madopark?+
The appropriate dose of Madopark is individualized by the prescribing clinician based on disease severity, patient age, and response to therapy. Dosage regimens are tailored during treatment initiation and adjusted over time to achieve optimal symptom control while minimizing adverse effects.
Is Madopark safe in pregnancy or breastfeeding?+
Safety data for Madopark during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Madopark from GNH USA?+
To request Madopark, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Madopark compare with other Parkinson's medications?+
Madopark combines levodopa with a peripheral decarboxylase inhibitor, offering higher central dopamine delivery than levodopa alone. Compared with dopamine agonists, it typically provides stronger symptom relief but may have a higher incidence of motor complications such as dyskinesia, requiring individualized therapy selection.
How should Madopark be stored and handled?+
Madopark tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.
How is Madopark administered?+
Madopark is taken orally with a glass of water, usually several times a day as directed by the prescriber. Tablets should be swallowed whole and not crushed or chewed unless specifically advised. Dosing times are often spaced to maintain steady plasma levels.
What are the most serious risks to watch for while taking Madopark?+
Serious risks include the development of dyskinesia (involuntary movements), hallucinations or psychotic symptoms, severe hypotension leading to fainting, and rare neuroleptic malignant‑like syndrome. Patients should report any sudden changes in mood, movement, or blood pressure to their healthcare provider promptly.
Who should not use Madopark?+
Madopark is contraindicated in individuals with known hypersensitivity to levodopa, benserazide, or any excipients, and in patients currently taking non‑selective MAO inhibitors. Caution is also advised for those with severe cardiovascular disease, uncontrolled hypertension, or a history of malignant neuroleptic syndrome.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Benserazide Hydrochloride, Levodopa
Route
Oral Use
Manufacturer
Roche Ab
Origin
EU

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