GNH USA

Europe — EMA

Madopar Depot (Benserazide Hydrochloride, Levodopa)

GNH USA supplies Madopar Depot (Levodopa/Benserazide), a precursor with DOPA decarboxylase inhibitor for Parkinson's disease. Request a quote for supply.

Benserazide Hydrochloride, Levodopa

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What is Benserazide Hydrochloride, Levodopa?

Levodopa, the active ingredient in Madopar Depot, is a dopamine precursor with DOPA decarboxylase inhibitor presented as a depot oral formulation for oral use. It treats Parkinson's disease in adults.

GNH USA supplies Madopar Depot as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Benserazide Hydrochloride, Levodopa used for?

Madopar Depot is an ant Parkinson agent that provides continuous dopaminergic stimulation for patients with Parkinson's disease.

Motor fluctuations: reduces OFF periods and improves motor control. Early-stage Parkinson's disease: enhances daily movement and reduces rigidity. Advanced Parkinson's disease: provides continuous dopaminergic stimulation to smooth symptom control.

What are the side effects of Benserazide Hydrochloride, Levodopa?

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Dizziness: may occur when standing quickly. - Headache: transient cranial discomfort. - Orthostatic hypotension: drop in blood pressure upon standing.

Serious or Rare Side Effects: - Dyskinesia: involuntary movements that can be disabling. - Psychiatric disturbances: hallucinations, confusion, or mood changes. - Severe hypotension: marked blood pressure fall requiring medical attention.

What precautions apply to Benserazide Hydrochloride, Levodopa?

Before initiating therapy, consider the following precautions: - Dose titration: adjust gradually under medical supervision. - Renal impairment: monitor renal function and adjust if needed. - Cardiovascular disease: use cautiously in patients with heart conditions. - Psychiatric history: monitor for hallucinations or mood alterations. - Concomitant MAO‑B inhibitors: avoid unless specifically prescribed. - Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture.

What does Benserazide Hydrochloride, Levodopa interact with?

Madopar Depot may interact with several medicines. Review the following groups:

Major Interactions (Avoid): - Non‑selective MAO inhibitors: risk hypertensive crisis. - Antipsychotics (e.g., haloperidol): block dopamine effect. - Iron supplements: reduce levodopa absorption.

Moderate Interactions (Monitor Closely): - COMT inhibitors: may increase levodopa levels. - SSRIs: possible serotonin syndrome. - Antihypertensives: additive blood pressure lowering.

Frequently asked questions

What is Madopar Depot used for?+
Madopar Depot is an oral depot formulation that combines levodopa with benserazide to provide continuous dopaminergic stimulation for patients with Parkinson's disease, helping to improve motor symptoms and reduce fluctuations.
How does levodopa work in Madopar Depot?+
Levodopa is a precursor that crosses the blood‑brain barrier and is converted into dopamine, replenishing the deficient neurotransmitter in Parkinson's disease. Benserazide inhibits peripheral conversion, ensuring more levodopa reaches the brain for a sustained effect.
What is the usual dose of Madopar Depot?+
The specific dose of Madopar Depot is determined individually by a qualified prescriber based on the patient’s clinical condition, response, and tolerability. No fixed regimen is provided here.
Is Madopar Depot safe during pregnancy or breastfeeding?+
Safety data for Madopar Depot in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Madopar Depot from GNH USA?+
To order Madopar Depot, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.
How does Madopar Depot compare with standard immediate‑release levodopa tablets?+
Madopar Depot offers a prolonged release profile, delivering levodopa more steadily over time, which can reduce motor fluctuations compared with immediate‑release tablets that require multiple daily doses and may cause peaks and troughs in symptom control.
What are the storage requirements for Madopar Depot?+
Madopar Depot should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the tablets out of reach of children.
How is Madopar Depot administered?+
Madopar Depot is taken orally, usually with a glass of water. It is designed as an extended‑release tablet, so it should be swallowed whole and not split, chewed, or crushed to maintain the intended release characteristics.
What are the most serious risks associated with Madopar Depot?+
Serious risks include dyskinesia (involuntary movements), psychiatric disturbances such as hallucinations or confusion, and severe hypotension. Patients should be monitored closely for these events, and any concerning symptoms should be reported to a healthcare professional promptly.
Who should not use Madopar Depot?+
Madopar Depot is contraindicated in patients with known hypersensitivity to levodopa, benserazide, or any excipients, and in individuals taking non‑selective MAO inhibitors. Caution is also advised for patients with severe cardiovascular disease, uncontrolled hypertension, or a history of malignant neuroleptic syndrome.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Benserazide Hydrochloride, Levodopa
Route
Oral Use
Manufacturer
Roche Norge As, Norway
Origin
EU

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