Macrogol - 1 A Pharma

Macrogol 3350, the active ingredient in Macrogol - 1 A Pharma, is an osmotic laxative presented as an oral powder for oral use. Combined with sodium hydrogen carbonate, potassium chloride and sodium chloride, it draws water into the intestinal lumen to soften stool and facilitate bowel cleansing in adults and children.

GNH USA supplies Macrogol - 1 A Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets EU quality standards and is manufactured under GMP conditions.

Macrogol 3350 is an osmotic laxative used to manage conditions involving impaired bowel transit.

- Constipation: softens stool and promotes regular bowel movements in patients with functional constipation. - Bowel preparation for colonoscopy: clears the intestinal tract to allow clear visualization during endoscopic procedures. - Fecal impaction: facilitates evacuation of hardened stool in cases of impaction.

Macrogol 3350 may be associated with a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Abdominal bloating: sensation of fullness or swelling in the abdomen. - Nausea: mild to moderate feeling of queasiness. - Flatulence: increased intestinal gas. - Diarrhea: loose stools occurring more frequently. - Abdominal pain: cramping or discomfort. - Headache: mild headache during treatment.

Serious or Rare Side Effects: - Severe dehydration: excessive fluid loss requiring medical attention. - Electrolyte imbalance: abnormal sodium or potassium levels. - Allergic reaction: rash, itching, swelling, or difficulty breathing. - Severe abdominal pain: persistent or worsening pain. - Rectal bleeding: blood in stool indicating mucosal injury.

When prescribing Macrogol 3350, consider the following precautions: - Avoid use in complete bowel obstruction: risk of perforation and worsening obstruction. - Caution in renal impairment: monitor electrolyte balance due to sodium and potassium content. - Use carefully in patients with inflammatory bowel disease flare: may exacerbate symptoms. - Pregnancy and lactation: consult a healthcare professional before use. - Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Macrogol 3350 can interact with other medications; monitor patients accordingly.

Major Interactions (Avoid): - Concurrent use of other osmotic laxatives: may cause severe dehydration and electrolyte imbalance. - High-dose diuretics: increase risk of electrolyte disturbances. - Intravenous electrolyte solutions: additive sodium and potassium load may lead to hypernatremia or hyperkalemia.

Moderate Interactions (Monitor Closely): - Antacids containing sodium bicarbonate: may augment sodium load. - NSAIDs: may increase risk of gastrointestinal irritation. - Antibiotics altering gut flora: could affect laxative efficacy.