GNH USA

Europe — EMA

Macrodantin

GNH USA supplies Macrodantin (Nitrofurantoin), a nitrofuran antibiotic for uncomplicated urinary tract infections and cystitis.

Nitrofurantoin

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What is Nitrofurantoin?

Nitrofurantoin, the active ingredient in Macrodantin, is a nitrofuran antibiotic presented as an oral tablet for systemic use. It is indicated for the treatment of uncomplicated urinary tract infections, particularly cystitis, and is commonly prescribed for adult patients with susceptible bacterial strains.

GNH USA supplies Macrodantin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with European Union pharmacopeial standards and is manufactured under GMP conditions to ensure consistent potency and safety globally.

What is Nitrofurantoin used for?

Macrodantin (nitrofurantoin) is used to treat infections of the urinary tract caused by susceptible bacteria.

- Uncomplicated urinary tract infection: eradicates the causative bacteria and resolves urinary symptoms. - Cystitis: reduces bacterial load in the bladder and alleviates inflammation. - Recurrent urinary tract infection prophylaxis: helps prevent recurrence when used long‑term under medical supervision.

What are the side effects of Nitrofurantoin?

Common Side Effects: - Nausea: mild stomach upset may occur. - Diarrhea: loose stools are reported. - Headache: transient headache may develop. - Metallic taste: altered taste sensation.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial lung disease or fibrosis. - Hepatic injury: elevated liver enzymes or hepatitis. - Hemolytic anemia: especially in patients with G6PD deficiency.

What precautions apply to Nitrofurantoin?

Before initiating therapy, consider the following precautions: - Assess renal function: adjust or avoid use in severe renal impairment. - Monitor for hypersensitivity: discontinue if rash, fever, or eosinophilia develop. - Avoid in patients with G6PD deficiency: risk of hemolysis. - Use with caution in pregnancy: category B, limited data; weigh benefits versus risks. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Nitrofurantoin interact with?

Nitrofurantoin may interact with several medicines; review the following:

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: reduce nitrofurantoin absorption. - Probenecid: decreases renal excretion, increasing toxicity risk. - Trimethoprim‑sulfamethoxazole: heightened risk of pulmonary toxicity. - Warfarin: may enhance anticoagulant effect.

Moderate Interactions (Monitor Closely): - Fluoroquinolones: additive neurotoxic potential. - NSAIDs: may increase risk of renal impairment. - Diuretics: elevate risk of crystalluria and kidney stones.

Frequently asked questions

What is Macrodantin used for?+
Macrodantin contains nitrofurantoin and is prescribed for the treatment of uncomplicated urinary tract infections, especially cystitis, in adult patients. It works against susceptible bacteria that cause these infections.
How does nitrofurantoin work?+
Nitrofurantoin is reduced by bacterial enzymes to reactive compounds that disrupt carbohydrate metabolism, impairing DNA, RNA and protein synthesis in the bacteria. This leads to bacterial cell death, particularly in the urinary tract where the drug concentrates.
What is the usual dose of Macrodantin?+
The dosage of Macrodantin is determined by the prescribing clinician based on the infection severity, patient renal function and local guidelines. Patients should follow the prescriber’s instructions and not alter the dose on their own.
Is Macrodantin safe in pregnancy or breastfeeding?+
Nitrofurantoin is classified as pregnancy category B, indicating no evidence of risk in animal studies but limited human data. It is generally avoided near term and during breastfeeding unless the benefits outweigh potential risks, as decided by a healthcare professional.
How do I order Macrodantin from GNH USA?+
To order Macrodantin, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Macrodantin compare with other urinary antibiotics?+
Compared with other agents such as trimethoprim‑sulfamethoxazole, nitrofurantoin has a narrow spectrum focused on common urinary pathogens and achieves high urinary concentrations. It is often chosen when resistance to broader agents is a concern, though it may be contraindicated in renal impairment.
How should Macrodantin be stored and handled?+
Macrodantin tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.
How is Macrodantin administered?+
Macrodantin is taken orally with a full glass of water, usually with food to reduce gastrointestinal upset. The tablet should be swallowed whole and not crushed or chewed unless specifically instructed by a healthcare provider.
What are the most serious risks associated with Macrodantin?+
Serious risks include pulmonary toxicity (interstitial lung disease or fibrosis), hepatic injury, and hemolytic anemia, especially in patients with glucose‑6‑phosphate dehydrogenase deficiency. Prompt medical attention is required if symptoms such as persistent cough, jaundice or dark urine develop.
Who should not use Macrodantin?+
Macrodantin should be avoided in patients with severe renal impairment (creatinine clearance <30 mL/min), known hypersensitivity to nitrofurantoin, G6PD deficiency, and in late pregnancy unless the prescriber determines the benefits outweigh the risks.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nitrofurantoin
Route
Oral Use
Manufacturer
Amdipharm Limited
Origin
EU

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