Macrodantin

Nitrofurantoin, the active ingredient in Macrodantin, is a nitrofuran antibiotic presented as an oral tablet for oral use. It treats uncomplicated urinary tract infections and cystitis by targeting bacterial metabolism. GNH USA supplies Macrodantin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Macrodantin is a nitrofuran antibiotic used to manage infections of the urinary tract. It acts directly on bacterial pathogens that cause these conditions. - Uncomplicated urinary tract infection: eradicates causative bacteria and resolves symptoms. - Acute cystitis: clears infection in the bladder and alleviates discomfort. - Prophylaxis of recurrent urinary tract infections: reduces the frequency of repeat infections when used as directed.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Loss of appetite: reduced desire to eat. - Diarrhea: loose stools occurring during therapy. - Headache: transient mild headache.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial lung disease presenting with cough and dyspnea. - Hepatic injury: elevated liver enzymes or jaundice. - Peripheral neuropathy: tingling or numbness in extremities.

Before prescribing Macrodantin, consider the following precautions. - Renal function: assess creatinine clearance; avoid if severely impaired. - Pregnancy: category B, but avoid use near term due to potential fetal risk. - G6PD deficiency: contraindicated because of hemolysis risk. - Elderly patients: monitor for reduced renal clearance and increased toxicity. - Antacid use: may decrease absorption; separate dosing by at least 2 hours. - Store at room temperature: keep in original container, protect from moisture.

Nitrofurantoin may interact with several medicines; monitor accordingly. Major Interactions (Avoid): - Antacids: reduce drug absorption, diminishing efficacy. - Probenecid: increases nitrofurantoin plasma levels, raising toxicity risk. - Warfarin: may enhance anticoagulant effect, requiring INR monitoring. Moderate Interactions (Monitor Closely): - Diuretics: affect renal function and drug excretion. - NSAIDs: potential additive renal impairment. - Oral contraceptives: possible reduction in contraceptive effectiveness.