GNH USA

Europe — EMA

Macorel

GNH USA supplies Macorel (Nifedipine), a calcium channel blocker for hypertension and angina pectoris, to hospitals and clinics worldwide. Request a quote.

Nifedipine

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1
Pack/s

What is Nifedipine?

Nifedipine, the active ingredient in Macorel, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension and angina pectoris in adult patients. GNH USA supplies Macorel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Nifedipine used for?

Nifedipine is a calcium channel blocker used to manage cardiovascular conditions.

Hypertension: lowers blood pressure by relaxing arterial smooth muscle. Angina pectoris: reduces myocardial oxygen demand and alleviates chest pain. Coronary artery disease: improves myocardial perfusion by decreasing vascular resistance.

What are the side effects of Nifedipine?

Common Side Effects: - Headache - Flushing - Peripheral edema - Dizziness - Tachycardia - Nausea

Serious or Rare Side Effects: - Severe hypotension - Myocardial infarction - Life‑threatening arrhythmias - Hepatic dysfunction - Allergic reactions such as rash or angioedema - Gingival hyperplasia

What precautions apply to Nifedipine?

Before initiating therapy, consider the following precautions.

Monitor blood pressure: check regularly after starting treatment. Assess cardiac status: use caution in patients with heart failure. Review concomitant medications: avoid strong CYP3A4 inhibitors. Adjust dose in hepatic impairment: consider reduced dosing. Store at ambient temperature: keep below 25°C, protect from moisture and light.

What does Nifedipine interact with?

Nifedipine may interact with several medicines; categorize as follows.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels. - Grapefruit juice: can raise nifedipine concentrations. - Other potent vasodilators: risk of severe hypotension.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may mask tachycardia. - Diuretics: additive blood‑pressure lowering effect. - Digoxin: possible increase in serum digoxin levels.

Frequently asked questions

What is Macorel used for?+
Macorel contains nifedipine, which is prescribed to lower high blood pressure (hypertension) and to relieve chest pain caused by reduced blood flow to the heart (angina pectoris). It may also be used in the broader management of coronary artery disease.
How does nifedipine work?+
Nifedipine blocks L‑type calcium channels in the smooth muscle of blood vessels and the heart. By preventing calcium entry, it relaxes arterial walls, reduces peripheral resistance, and lowers blood pressure while also decreasing the heart's oxygen demand, helping to control angina.
What is the usual dose of Macorel?+
The appropriate dose of Macorel is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concurrent medications. Dosage adjustments are made during follow‑up visits to achieve optimal blood‑pressure control or angina relief.
Is Macorel safe during pregnancy or breastfeeding?+
Safety data for nifedipine in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Macorel from GNH USA?+
To request Macorel, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Macorel compare with other antihypertensive drugs?+
Compared with other antihypertensives, nifedipine offers rapid vasodilation and is effective for both hypertension and angina. Unlike beta‑blockers, it does not reduce heart rate, and unlike ACE inhibitors, it works directly on vascular smooth muscle. Choice of therapy depends on patient‑specific factors and comorbidities.
How should Macorel be stored and handled?+
Macorel should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.
How is Macorel administered?+
Macorel is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the prescribing physician’s instructions regarding timing and whether the dose should be taken on an empty stomach.
What are the most serious risks to watch for?+
Serious risks include severe hypotension, myocardial infarction, life‑threatening arrhythmias, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience fainting, chest pain, rapid heartbeat, or signs of an allergic response.
Who should not use Macorel?+
Macorel is contraindicated in patients with known hypersensitivity to nifedipine or other dihydropyridine calcium channel blockers, and in those with severe aortic stenosis or uncontrolled heart failure. Clinicians must evaluate each patient’s medical history before prescribing.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nifedipine
Route
Oral Use
Manufacturer
Elpen Pharmaceutical Co. Inc.
Origin
EU

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