Lipiodol Ultra-Fluide

Ethyl esters of iodised fatty acids from poppyseed oil, the active ingredient in Lipiodol Ultra-Fluide, is an iodinated contrast media presented as a sterile oil for intralymphatic use. It provides radiopaque imaging enhancement for lymphatic, joint and tumor‑related procedures in adult patients.

GNH USA supplies Lipiodol Ultra-Fluide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lipiodol Ultra-Fluide is used as an iodinated contrast agent for imaging and interventional procedures involving the lymphatic system and other targeted structures. - Lymphangiography: visualises lymphatic vessels and nodes to assess obstruction or leakage. - Arthrography: enhances joint space imaging to detect cartilage defects, tears or inflammatory changes. - Tumor embolization: provides contrast during arterial embolisation of hepatic or other solid tumours to guide catheter placement. - Radiographic contrast enhancement: improves X‑ray visibility of vascular or soft‑tissue structures during diagnostic studies.

Adverse reactions may occur following intralymphatic administration of Lipiodol Ultra-Fluide.

Common Side Effects: - Warmth or flushing at the injection site: transient sensation of heat. - Mild pain or discomfort: localized soreness during or after injection. - Nausea or vomiting: occasional gastrointestinal upset. - Mild allergic skin reaction: erythema or urticaria at the site.

Serious or Rare Side Effects: - Severe hypersensitivity reaction: anaphylaxis requiring emergency treatment. - Pulmonary embolism: rare migration of oil droplets to the lungs. - Renal impairment: contrast‑induced nephropathy in susceptible patients. - Cardiovascular collapse: hypotension or arrhythmia in extreme cases.

Prior to using Lipiodol Ultra-Fluide, clinicians should consider several safety measures. - Assess iodine allergy: screen patients for known hypersensitivity to iodinated agents. - Evaluate renal function: check serum creatinine and eGFR, especially in at‑risk individuals. - Use lowest effective volume: limit the amount injected to reduce systemic exposure. - Monitor vital signs: observe blood pressure, heart rate and oxygen saturation during administration. - Avoid use in uncontrolled hyperthyroidism: excess iodine may exacerbate thyroid hormone release. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Lipiodol Ultra-Fluide may interact with other medications or agents that affect iodine handling or renal function.

Major Interactions (Avoid): - Thyroid hormone therapy: excess iodine can alter hormone levels. - Other iodinated contrast agents: cumulative iodine load increases risk of toxicity. - Nephrotoxic drugs (e.g., aminoglycosides, amphotericin B): may potentiate renal injury.

Moderate Interactions (Monitor Closely): - Diuretics: may affect fluid balance and contrast distribution. - ACE inhibitors or ARBs: can predispose to contrast‑induced nephropathy. - NSAIDs: may impair renal perfusion when combined with contrast media.