Lipidem

Omega-3-acid triglycerides, the active ingredient in Lipidem, is a parenteral lipid emulsion presented as an intravenous emulsion for intravenous use. It provides essential fatty acids and calories for patients requiring parenteral nutrition, helping prevent essential fatty acid deficiency.

GNH USA supplies Lipidem as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Lipidem is employed in clinical nutrition to address lipid needs in patients receiving parenteral feeding. - Parenteral nutrition: supplies calories and essential fatty acids to patients unable to receive enteral feeding. - Essential fatty acid deficiency prevention: delivers omega‑3 fatty acids to maintain membrane integrity in patients on long‑term lipid‑free parenteral solutions. - Critical care support: supports energy metabolism and cell‑membrane synthesis in critically ill patients receiving total parenteral nutrition.

Lipidem may be associated with a range of infusion‑related reactions.

Common Side Effects: - Hypertriglyceridemia: elevated serum triglyceride levels during therapy. - Fever or chills: transient temperature rise during infusion. - Infusion site reactions: erythema, pain, or swelling at the catheter site. - Nausea or headache: mild gastrointestinal or neurologic discomfort.

Serious or Rare Side Effects: - Fat overload syndrome: severe hyperlipidaemia with hepatic and respiratory compromise. - Allergic reactions: anaphylaxis or severe hypersensitivity, especially in patients with soy or egg phospholipid allergy. - Pulmonary embolism: rare embolic events related to lipid particles. - Hepatic dysfunction: marked elevation of liver enzymes or cholestasis. - Thrombocytopenia: reduced platelet count potentially leading to bleeding.

When using Lipidem, clinicians should observe several safety measures. - Monitor triglyceride levels: check serum triglycerides regularly to avoid fat overload. - Assess liver function: perform hepatic enzyme tests before and during therapy. - Caution in hyperlipidaemia: adjust dosing or consider alternative lipid sources. - Avoid in known soy or egg phospholipid hypersensitivity: screen patients for allergies. - Adjust in impaired metabolism: reduce infusion rates for patients with compromised lipid clearance. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Lipidem can interact with other agents that affect lipid metabolism or add to lipid load.

Major Interactions (Avoid): - Concurrent lipid emulsions: risk of cumulative fat overload. - Propofol infusion: both provide lipid calories, increasing overload risk. - High‑dose heparin: may exacerbate hypertriglyceridaemia.

Moderate Interactions (Monitor Closely): - Corticosteroids: can raise serum triglycerides, requiring monitoring. - Beta‑blockers: may alter lipid metabolism, necessitating periodic lipid panels. - Diuretics: affect fluid balance; monitor for volume status during infusion.