Lipidem

Omega-3-acid triglycerides, the active ingredient in Lipidem, is a parenteral lipid emulsion presented as an intravenous lipid emulsion for intravenous use. It provides essential fatty acids and calories for patients receiving parenteral nutrition, helping prevent essential fatty acid deficiency and supporting cellular membrane integrity.

GNH USA supplies Lipidem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Lipidem is used in parenteral nutrition to supply essential fatty acids and calories.

- Total parenteral nutrition (TPN): supplies calories and essential fatty acids to patients unable to receive enteral feeding. - Essential fatty acid deficiency prevention: provides omega‑3 fatty acids to maintain cell membrane integrity. - Critical or surgical patients receiving TPN: supports energy needs and reduces risk of deficiency during intensive care.

Lipidem may cause a range of infusion‑related reactions.

Common Side Effects: - Hypertriglyceridemia: elevated blood triglyceride levels. - Fever or chills during infusion. - Infusion site erythema or pain. - Elevated liver enzymes (ALT/AST). - Electrolyte disturbances (e.g., hypophosphatemia).

Serious or Rare Side Effects: - Fat overload syndrome: severe hyperlipidemia with organ dysfunction. - Pulmonary embolism or respiratory distress. - Anaphylactic or severe allergic reactions. - Infection risk from contaminated infusion. - Thrombocytopenia or coagulation abnormalities.

When using Lipidem, clinicians should observe several safety measures.

- Triglyceride monitoring: check serum triglyceride levels regularly. - Liver function: assess hepatic enzymes before and during therapy. - Allergy assessment: verify no known hypersensitivity to soy, egg, or fish oils. - Hyperlipidemia caution: use carefully in patients with pre‑existing lipid disorders. - Concomitant lipid sources: avoid combining with other lipid emulsions to prevent fat overload. - Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Lipidem can interact with other medications affecting lipid metabolism or coagulation.

Major Interactions (Avoid): - Concurrent lipid emulsions (e.g., propofol): risk of severe hypertriglyceridemia. - High‑dose heparin therapy: may exacerbate triglyceride elevation.

Moderate Interactions (Monitor Closely): - Anticoagulants (warfarin, DOACs): lipid infusion may alter INR or bleeding risk. - Corticosteroids: can increase serum triglyceride concentrations. - Certain antibiotics (e.g., ceftriaxone): may precipitate when mixed with lipid emulsions. - Immunosuppressants: monitor for altered drug levels due to changes in plasma protein binding.