Lioresal Intrathecal

Baclofen, the active ingredient in Lioresal Intrathecal, is a GABA_B receptor agonist presented as an intrathecal solution for direct spinal administration. It is used to reduce muscle spasticity in patients with multiple sclerosis or spinal cord injury, providing targeted relief where oral therapy may be insufficient.

GNH USA supplies Lioresal Intrathecal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and specialty clinics worldwide. The product complies with EU pharmaceutical standards and is manufactured under GMP conditions.

Lioresal Intrathecal, an intrathecal antispastic agent, is indicated for conditions involving central nervous system‑mediated muscle hypertonia. - Multiple sclerosis spasticity: reduces muscle tone and improves mobility in patients with MS‑related spasticity. - Spinal cord injury spasticity: alleviates involuntary muscle contractions and facilitates rehabilitation in individuals with SCI‑induced spasticity. - Severe refractory spasticity: provides targeted relief when oral antispasmodics are ineffective.

Baclofen administered intrathecally may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Headache: mild to moderate pain in the head. - Drowsiness: increased sleepiness or fatigue. - Nausea: feeling of queasiness. - Injection site discomfort: pain or irritation at the catheter insertion point.

Serious or Rare Side Effects: - Respiratory depression: reduced breathing effort that may require monitoring. - Seizures: occurrence of convulsive episodes. - Severe hypotonia: marked loss of muscle tone. - Infection: meningitis or catheter‑related infections.

When using intrathecal baclofen, clinicians should observe specific precautions to minimize risks and ensure safe administration. - Patient selection: assess for contraindications such as allergy to baclofen or active infection at the catheter site. - Dose titration: adjust dosage gradually under specialist supervision to avoid abrupt withdrawal or overdose. - Monitoring: observe for signs of respiratory depression, hypotension, or neurological changes during initiation. - Catheter care: maintain sterile technique and regularly inspect the intrathecal catheter for blockage or infection. - Withdrawal risk: abrupt discontinuation can cause severe rebound spasticity; ensure continuous delivery. - Store at ambient temperature: keep the solution below 25°C in the original container, protect from light and moisture.

Baclofen may interact with other medicines, altering its efficacy or increasing adverse effects.

Major Interactions (Avoid): - Opioids: combined use can enhance central nervous system depression, increasing risk of respiratory depression. - Benzodiazepines: additive sedative effects may lead to excessive drowsiness or hypotension. - Antihypertensives: concurrent use may cause pronounced blood pressure lowering.

Moderate Interactions (Monitor Closely): - Anticonvulsants: may require dose adjustments as baclofen can affect seizure threshold. - Muscle relaxants: additive antispastic effects could increase weakness. - Alcohol: can potentiate sedation and dizziness.