GNH USA

Europe — EMA

Lioresal Intrathecal

GNH USA supplies Lioresal Intrathecal (Baclofen), a GABA_B receptor agonist for spasticity in multiple sclerosis, spinal cord injury and cerebral palsy.

Baclofen

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What is Baclofen?

Baclofen, the active ingredient in Lioresal Intrathecal, is a GABA_B receptor agonist presented as an intrathecal solution for intrathecal use. It is employed to manage spasticity associated with multiple sclerosis, spinal cord injury, and cerebral palsy in patients requiring targeted spinal delivery. GNH USA supplies Lioresal Intrathecal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Baclofen used for?

Lioresal Intrathecal acts on the central nervous system to reduce abnormal muscle tone in several neurological conditions.

Multiple sclerosis–related spasticity: reduces muscle stiffness and improves functional mobility. Spinal cord injury–associated spasticity: diminishes involuntary muscle contractions and facilitates positioning. Cerebral palsy spasticity: helps control muscle rigidity and supports therapeutic rehabilitation.

What are the side effects of Baclofen?

Lioresal Intrathecal may cause a range of adverse reactions, ranging from mild to severe.

Common Side Effects: - Dizziness - Somnolence - Nausea - Headache - Weakness - Urinary retention

Serious or Rare Side Effects: - Respiratory depression - Severe hypotension - Seizures - Catheter‑site infection - Hallucinations - Anaphylactic reactions

What precautions apply to Baclofen?

Careful assessment and monitoring are required when using intrathecal baclofen.

Dose titration: adjust under specialist supervision to balance efficacy and tolerability. Renal impairment: monitor because baclofen is primarily excreted unchanged by the kidneys. Hepatic impairment: use caution; dose may need reduction. Concomitant CNS depressants: avoid additive sedation and respiratory depression. Pregnancy: safety not established; weigh potential risks against benefits. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Baclofen interact with?

Baclofen can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid): - Opioids: additive respiratory depression. - Benzodiazepines: increased sedation and risk of coma. - Alcohol: potentiates sedative effects. - Other GABAergic agents: severe CNS depression.

Moderate Interactions (Monitor Closely): - Antihypertensives: may augment hypotensive effect. - Diuretics: can affect renal clearance of baclofen.

Frequently asked questions

What is Lioresal Intrathecal used for?+
Lioresal Intrathecal is an intrathecal formulation of baclofen used to treat severe spasticity in conditions such as multiple sclerosis, spinal cord injury, and cerebral palsy. It delivers the medication directly into the cerebrospinal fluid, providing targeted relief of muscle tone abnormalities when oral therapies are insufficient.
How does baclofen work in Lioresal Intrathecal?+
Baclofen acts as an agonist at GABA_B receptors in the spinal cord. By activating these inhibitory receptors, it reduces the release of excitatory neurotransmitters, dampening spinal reflex activity. This leads to a decrease in muscle hyperactivity and spasticity, improving patient mobility and comfort.
What is the usual dose of Lioresal Intrathecal?+
The dosing regimen for Lioresal Intrathecal is individualized and determined by the prescribing specialist. Doses are titrated based on clinical response and tolerability, with adjustments made through the implanted pump system under professional supervision.
Is Lioresal Intrathecal safe during pregnancy or breastfeeding?+
Safety data for intrathecal baclofen in pregnancy and lactation are limited. The product carries an unknown pregnancy category, and clinicians must evaluate potential risks versus benefits. Breastfeeding considerations should also be discussed with a healthcare provider.
How do I order Lioresal Intrathecal from GNH USA?+
To request Lioresal Intrathecal, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.
How does Lioresal Intrathecal compare with oral baclofen?+
Intrathecal baclofen delivers the drug directly to the spinal cord, achieving higher local concentrations with lower systemic exposure compared with oral baclofen. This often results in greater spasticity control and fewer systemic side effects, making it suitable for patients who do not respond adequately to oral therapy.
What are the storage and handling requirements for Lioresal Intrathecal?+
Lioresal Intrathecal should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Maintain the cold chain during transport and keep the solution in its original packaging until use.
How is Lioresal Intrathecal administered?+
The product is administered via an implanted intrathecal pump that delivers a continuous, programmable infusion of baclofen into the cerebrospinal fluid. A qualified clinician performs the surgical implantation and subsequent pump programming.
What are the most serious risks associated with Lioresal Intrathecal?+
Serious risks include respiratory depression, severe hypotension, seizures, catheter‑site infections, hallucinations, and rare anaphylactic reactions. Prompt medical attention is required if any of these events occur.
Who should not use Lioresal Intrathecal?+
Patients with known hypersensitivity to baclofen or any formulation component should avoid the product. It is also contraindicated in individuals with severe renal failure, uncontrolled infection at the catheter site, or those for whom intrathecal therapy is medically inappropriate.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Baclofen
Route
Intrathecal Use
Manufacturer
Novartis Pharma Gmbh
Origin
EU

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