GNH USA

Europe — EMA

Lioresal

GNH USA supplies Lioresal (Baclofen), a muscle relaxant for spasticity in multiple sclerosis and spinal cord injury. Request a quote for global supply.

Baclofen

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What is Baclofen?

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as a tablet for oral use. It treats spasticity associated with multiple sclerosis, spinal cord injury, and other central nervous system disorders causing muscle hypertonia.

GNH USA supplies Lioresal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Baclofen used for?

Baclofen is used to manage spasticity, a condition characterized by increased muscle tone, in several neurological disorders.

- Multiple sclerosis: reduces muscle stiffness and improves mobility. - Spinal cord injury: decreases involuntary muscle contractions and facilitates rehabilitation. - Other central nervous system disorders causing muscle hypertonia: alleviates excessive muscle tone.

What are the side effects of Baclofen?

Baclofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Dizziness - Drowsiness - Weakness - Fatigue - Nausea - Headache

Serious or Rare Side Effects: - Seizures - Hallucinations - Respiratory depression - Severe hypotension - Allergic reactions (rash, angioedema) - Urinary retention

What precautions apply to Baclofen?

When prescribing baclofen, clinicians should consider several safety factors.

- Renal impairment: adjust dose if needed. - Hepatic impairment: monitor liver function and consider dose modification. - History of seizures: use with caution and monitor closely. - Concurrent CNS depressants: avoid additive sedation. - Pregnancy: safety not established; avoid unless essential. - Store at ambient temperature: keep in the original container, protect from moisture and light.

What does Baclofen interact with?

Baclofen can interact with other medications, requiring careful management.

Major Interactions (Avoid): - Alcohol: may enhance central nervous system depression. - Opioids: increased risk of respiratory depression. - Anticonvulsants (e.g., carbamazepine): may reduce baclofen plasma levels. - CNS depressants (benzodiazepines): additive sedation.

Moderate Interactions (Monitor Closely): - Antihypertensives: may potentiate hypotensive effect. - Anticholinergics: may increase urinary retention.

Frequently asked questions

What conditions is Lioresal (baclofen) used for?+
Lioresal, containing baclofen, is prescribed to reduce spasticity in patients with multiple sclerosis, spinal cord injury, and other neurological disorders that cause increased muscle tone. By relaxing overactive muscles, it helps improve mobility and comfort.
How does baclofen work to relieve spasticity?+
Baclofen binds to GABA_B receptors in the spinal cord and brain, decreasing the release of excitatory neurotransmitters. This inhibition dampens spinal reflexes, leading to reduced muscle tone and lessened spasticity.
What is the usual dose of Lioresal?+
The dosage of Lioresal is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s condition, response, and tolerance. Patients should follow the prescribing physician’s instructions.
Is baclofen safe during pregnancy or breastfeeding?+
The safety of baclofen in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.
How do I order Lioresal from GNH USA?+
To request Lioresal, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.
How does Lioresal compare with other antispastic agents?+
Baclofen is a GABA_B agonist, whereas alternatives such as tizanidine act on alpha‑2 adrenergic receptors and diazepam enhances GABA_A activity. Baclofen’s mechanism provides targeted reduction of spinal reflexes, often resulting in fewer sedative effects compared with benzodiazepines, but individual response varies.
What are the recommended storage conditions for Lioresal tablets?+
Lioresal tablets should be stored at ambient temperature, below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.
How is Lioresal administered?+
Lioresal is taken orally as a tablet. Patients should swallow the tablet whole with water, preferably at the same times each day. The prescriber may adjust the dose gradually to achieve the desired therapeutic effect while monitoring tolerance.
What are the most serious risks associated with baclofen therapy?+
Serious risks include seizures, severe hypotension, respiratory depression, and allergic reactions such as rash or angioedema. Patients should seek immediate medical attention if they experience any of these symptoms while on baclofen.
Who should not use Lioresal?+
Lioresal is contraindicated in individuals with known hypersensitivity to baclofen or any tablet excipients. Caution is advised for patients with severe renal or hepatic impairment, uncontrolled epilepsy, or those taking other central nervous system depressants without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Baclofen
Route
Oral Use
Manufacturer
Novartis Pharmaceuticals Uk Limited
Origin
EU

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