Lioresal

Baclofen, the active ingredient in Lioresal, is a GABA_B receptor agonist presented as an oral formulation for systemic use. It is used to reduce muscle spasticity in neurological conditions such as multiple sclerosis, spinal cord injury, and cerebral palsy.

GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lioresal (baclofen) is indicated for conditions involving abnormal muscle tone and spasticity. - Multiple sclerosis spasticity: helps relax stiff muscles and improve mobility. - Spinal cord injury spasticity: reduces involuntary muscle contractions and pain. - Cerebral palsy spasticity: decreases muscle tightness to aid functional movement.

Adverse reactions may occur with baclofen therapy and should be monitored.

Common Side Effects: - Drowsiness: mild to moderate sedation. - Dizziness: sensation of light‑headedness. - Weakness: reduced muscle strength. - Nausea: mild gastrointestinal upset. - Headache: transient cranial discomfort.

Serious or Rare Side Effects: - Seizures: potential for convulsive activity. - Respiratory depression: reduced breathing effort. - Hypotension: significant drop in blood pressure. - Hallucinations or psychosis: altered mental status. - Allergic reactions: rash, itching, swelling.

Before initiating baclofen therapy, consider the following safety measures. - Renal impairment: adjust dose if kidney function is reduced. - Hepatic disease: monitor liver function and use cautiously. - Concomitant CNS depressants: avoid additive sedation. - Abrupt discontinuation: taper gradually to prevent withdrawal. - Pregnancy: assess risk‑benefit, limited data available. - Store at ambient temperature: keep below 25°C in original container, protect from moisture.

Baclofen may interact with other medications, requiring careful management.

Major Interactions (Avoid): - Opioids: combined CNS depression can be severe. - Benzodiazepines: additive sedative effects. - Antihypertensives: may enhance hypotensive response.

Moderate Interactions (Monitor Closely): - Anticonvulsants: may alter seizure threshold. - Alcohol: increases drowsiness and dizziness. - Anticholinergics: may exacerbate constipation.