Lioresal

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as an oral tablet for oral use. It is used to reduce muscle tone and manage spasticity in conditions such as multiple sclerosis and spinal cord injury.

GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for global healthcare providers. Our distribution network ensures timely delivery and regulatory compliance across diverse markets.

Lioresal (baclofen) is indicated for conditions involving abnormal muscle tone and spasticity.

- Multiple sclerosis–related spasticity: decreases muscle stiffness, reduces involuntary spasms, and can improve walking ability. - Spinal cord injury–associated spasticity: lessens frequency and intensity of muscle contractions, aiding daily activities. - Other muscle spasticity conditions: helps control abnormal tone in disorders such as cerebral palsy or post‑stroke spasticity.

Baclofen may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Dizziness - Drowsiness or fatigue - Nausea or gastrointestinal discomfort - Weakness or reduced muscle strength

Serious or Rare Side Effects: - Seizures or convulsions - Hallucinations or psychotic symptoms - Severe hypotension or cardiovascular collapse - Respiratory depression, especially after abrupt discontinuation - Allergic reactions such as rash, angioedema, or anaphylaxis - Cardiac arrhythmias

When prescribing baclofen, clinicians should consider several safety measures to minimize risks.

- Assess renal function: dose adjustment may be required in impaired clearance. - Monitor for abrupt discontinuation: sudden stop can precipitate withdrawal seizures. - Avoid use in patients with known hypersensitivity to baclofen or excipients. - Caution in individuals with epilepsy or a history of seizures. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Baclofen can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Central nervous system depressants (e.g., alcohol, benzodiazepines, opioids): may enhance sedation and respiratory depression. - Anticonvulsants that lower seizure threshold (e.g., tramadol): can increase risk of seizures.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: additive blood‑pressure‑lowering effect may cause hypotension. - CYP450 inhibitors (e.g., erythromycin): may modestly increase baclofen plasma levels. - Drugs affecting renal excretion (e.g., NSAIDs): monitor for accumulation in renal impairment.