Lioresal

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as an oral tablet for oral use. It is indicated for the management of spasticity associated with multiple sclerosis, spinal cord injury, and other neurological conditions that cause increased muscle tone. GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Lioresal (baclofen) acts on the central nervous system to reduce abnormal muscle tone in various spastic disorders. - Spasticity associated with multiple sclerosis: decreases muscle stiffness and improves mobility. - Spasticity due to spinal cord injury: lessens involuntary muscle contractions and facilitates functional movement. - Muscle spasticity of other origins: helps control rigidity and enhances daily activity performance.

Adverse reactions may occur with baclofen therapy and vary in frequency and severity.

Common Side Effects: - Drowsiness - Dizziness - Weakness or fatigue - Nausea - Headache - Dry mouth

Serious or Rare Side Effects: - Seizures - Hallucinations or psychosis - Respiratory depression - Severe hypotension - Allergic reactions (rash, angioedema) - Cardiac arrhythmias

Baclofen requires careful monitoring in several clinical situations. - Renal impairment: dose adjustment and close observation are recommended. - Hepatic dysfunction: consider reduced dosing and monitor liver function. - Concomitant CNS depressants: increased risk of sedation and respiratory depression. - Abrupt discontinuation: may cause withdrawal symptoms such as rebound spasticity or seizures. - Pregnancy and lactation: safety not established; weigh benefits against potential risks. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Baclofen can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Alcohol: potentiates central nervous system depression. - Opioids: combined use may cause severe respiratory depression. - Antihistamines: can enhance sedative effects.

Moderate Interactions (Monitor Closely): - Anticonvulsants: may reduce baclofen's antispastic effect. - CYP450 inhibitors (e.g., erythromycin): possible increase in baclofen plasma levels. - Diuretics: may augment hypotensive response.