Lioresal

Baclofen, the active ingredient in Lioresal, is a muscle relaxant presented as an oral tablet for oral use. It is employed to reduce muscle spasticity in conditions such as multiple sclerosis, spinal cord injury, and cerebral palsy. It works by activating GABA_B receptors in the spinal cord, thereby diminishing reflex activity and muscle tone.

GNH USA supplies Lioresal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance, regulatory compliance, and reliable logistics for global distribution.

Baclofen is used to manage spasticity disorders affecting the central nervous system.

Multiple sclerosis–related spasticity: reduces muscle tone, eases stiffness, and improves gait and functional mobility. Spinal cord injury–associated spasticity: decreases involuntary muscle contractions, lessens pain, and enhances ability to perform daily activities. Cerebral palsy spasticity: alleviates muscle stiffness, improves range of motion, and supports better motor function.

Baclofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Dizziness - Drowsiness - Weakness - Fatigue - Nausea - Headache

Serious or Rare Side Effects: - Seizures - Hallucinations - Severe hypotension - Respiratory depression - Allergic reactions (rash, angioedema) - Urinary retention

Before initiating therapy, consider the following precautions.

Renal impairment: dose may need adjustment and monitoring of renal function. Hepatic impairment: use with caution and monitor liver enzymes. History of seizures: baclofen can lower seizure threshold; monitor closely. Concurrent CNS depressants: increased risk of excessive sedation and respiratory depression. Pregnancy: safety not established; discuss risks with healthcare provider. Store at ambient temperature: keep in original container, protect from moisture and heat.

Baclofen can interact with several medicines; review patient medication lists.

Major Interactions (Avoid): - Alcohol: increased central nervous system depression. - Opioids: additive sedation and risk of respiratory depression. - Antihypertensives: may enhance hypotensive effect.

Moderate Interactions (Monitor Closely): - Anticonvulsants: may reduce baclofen efficacy. - CYP450 inhibitors: may increase baclofen plasma levels. - Diuretics: may potentiate hypotension.